Guillaume De Bo

Guillaume De Bo is a researcher in the Department of Chemistry at the University of Manchester.[3] His research is based on Mechanochemistry, where he investigates techniques in the control of mechanical forces at molecular levels for application in synthetic chemistry, materials and mechanosensors.[2][3]

Guillaume De Bo
Guillaume De Bo
Born
Guillaume De Bo

Brussels, Belgium[1]
Alma materUniversity of Louvain (Msc., PhD)
Known forMolecular Mechanics
Molecular Machines
AwardsThieme Chemistry Journals Award (2020)
Royal Society University Research Fellowship (2015)[1]
Scientific career
Fieldsmechanochemistry[2]
InstitutionsUniversity of Manchester
ThesisSynthesis of angular triquinanes (2009)
Doctoral advisorProf. István E. Markó
Websitewww.deboresearchgroup.com

Education

Guillaume completed his Master of Science degree at University of Louvain in 2004 where he finished his final year project with Prof. István E. Markó on the development of platinum-based catalysts for the hydrosilylation of alkynes.[4][5] He continued to complete his PhD with Prof. István E. Markó on the synthesis of angular triquinanes at the same university and successfully completed it in 2009.[4][5]

Research and career

Guillaume completed his postdoctoral research with Prof. Jean-François Gohy and Prof. Charles-André Fustin at University of Louvain where he worked on the assembly of mechanically-linked block copolymers.[4] In 2011, he joined Prof. David Leigh's research group at The University of Edinburgh to work on the development of molecular machines.[4][6] He then joined the University of Manchester after obtaining a Royal Society University Research Fellowship in 2016.[6]

Guillaume's research is based on Mechanochemistry, where he investigates techniques in the control of mechanical forces at molecular levels for application in synthetic chemistry, materials and mechanosensors.[2][3] He is also an associate member of the Royal Society of Chemistry Macrocyclic and Supramolecular Chemistry Group from 2015, and also worked as the secretary of the Polymer Science Committee from 2014 - 2017.[7][8] He was a guest editor in a Supramolecular Chemistry Special Issue on Emerging Supramolecular Chemistry in the UK (2017 - 2018) and worked as the next - generation adviser for Chem (cell press) during 2016 - 2019.[6][9]

Notable work

In 2020, Guillaume showed the that the dissociation of a mechanophore built around an N-heterocyclic carbene precursor proceeds with the rupture of a C–C bond through concomitant heterolytic, concerted and homolytic pathways using 1H- and 19F-nuclear magnetic resonance spectroscopy in combination with deuterium labelling.[10] Normally, a chemical reaction occurs via a radical, concerted or ionic mechanism and transformations such as this where all these mechanisms are involved is extremely rare. The research discovered how molecular tuning influences mechanism which could be used in self-healing polymers or in plastics that break down upon mechanical activation.[11] In the same year, Guillaume showed how the ability of the two rings in [2]catenane to rotate alone each other enables [2]catenane to be used as a mechanical protecting group via the diversion of technical forces away from a mechanically active functional group embedded in one of its rings. This approach showed a new way to control the mechanical activity of a mechanophore.[12][13]

Awards, honours and nominations

Major Publications
  • De Bo, Guillaume; Nixon, Robert (2020). "Three concomitant C–C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor". Nature Chemistry. 12 (9): 826–831. Bibcode:2020NatCh..12..826N. doi:10.1038/s41557-020-0509-1. PMID 32690898. S2CID 220656588.
  • De Bo, Guillaume; Zhang, Min (2020). "A Catenane as a Mechanical Protecting Group". J. Am. Chem. Soc. 142 (11): 5029–5033. doi:10.1021/jacs.0c01757. PMID 32131588.
  • De Bo, Guillaume; Zhang, Min; Stevenson, Richard (2020). "Mechanical activation of polymers containing two adjacent mechanophores". Polymer Chemistry. 11 (16): 2864–2868. doi:10.1039/D0PY00279H.
  • De Bo, Guillaume; Zhang, Min (2018). "Impact of a Mechanical Bond on the Activation of a Mechanophore". J. Am. Chem. Soc. 140 (10): 12724–12727. doi:10.1021/jacs.8b08590. PMID 30248265.
  • De Bo, Guillaume (2018). "Mechanochemistry of the mechanical bond". Chemical Sciecne. 9 (1): 15–21. doi:10.1039/C7SC04200K. PMC 5874759. PMID 29629069.

References
  1. Royal Society of Chemistry. "Dr Guillaume De Bo (Profile)". Retrieved 28 September 2020.
  2. "Dr Guillaume De Bo (Google Scholar)". Retrieved 28 September 2020.
  3. University of Manchester. "Dr Guillaume De Bo(Research)". Retrieved 28 September 2020.
  4. University of Manchester. "Dr Guillaume De Bo(Overview)". Retrieved 28 September 2020.
  5. "Research Gate:Dr Guillaume De Bo". Retrieved 28 September 2020.
  6. "About Guillaume De Bo". Retrieved 28 September 2020.
  7. Royal Society of Chemistry. "Macrocyclic and Supramolecular Chemistry Group". Retrieved 28 September 2020.
  8. Polymer Science. "RAPS". Retrieved 28 September 2020.
  9. De Bo, Guillaume; Serpell, Christopher J.; Kitchen, Jonathan A. (2017). "Emerging investigators in the UK – editorial". Supramolecular Chemistry. 30 (9): 731. doi:10.1080/10610278.2018.1475606. S2CID 104741465.
  10. De Bo, Guillaume; Nixon, Robert (2020). "Three concomitant C–C dissociation pathways during the mechanical activation of an N-heterocyclic carbene precursor". Nature Chemistry. 12 (9): 826–831. Bibcode:2020NatCh..12..826N. doi:10.1038/s41557-020-0509-1. PMID 32690898. S2CID 220656588.
  11. Gomollon-Bel, fernando (3 August 2020). "Triple mechanochemistry mechanism might be a first for organic chemistry". Retrieved 28 September 2020.
  12. De Bo, Guillaume; Zhang, Min (2020). "A Catenane as a Mechanical Protecting Group". J. Am. Chem. Soc. 142 (11): 5029–5033. doi:10.1021/jacs.0c01757. PMID 32131588.
  13. Kramer, Katrina (24 March 2020). "Mechanical protecting group shields molecules from stress and strain". Retrieved 28 September 2020.
  14. Chemistry PASS Scheme, University of Manchester. "ChemStudent's Awards 2020 Nominees". Retrieved 28 September 2020.
  15. Thieme Chemistry. "Thieme Chemistry Journal Award winners (2020)". Retrieved 28 September 2020.
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