Gurmarin

Gurmarin is a 35-residue polypeptide from the Asclepiad vine Gymnema sylvestre (Gurmar). It has been utilised as a pharmacological tool in the study of sweet-taste transduction because of its ability to selectively inhibit the neural response to sweet tastants in rats.[2] As a sweet-taste-suppressing protein, gurmarin is only active on rodent sweet taste receptors but not on that of humans. ref: Appl Microbiol Biotechnol. 2012 Nov;96(3):619-30

Gurmarin
Structure of gurmarin, a sweet taste-suppressing polypeptide.[1]
Identifiers
SymbolGurmarin
PfamPF11410
InterProIPR010485
SCOP21gur / SCOPe / SUPFAM
OPM superfamily112
OPM protein1c4e
Gurmarin
Identifiers
OrganismGymnema sylvestre
Symbol?
PDB1c4e
UniProtP25810

References

  1. Arai K, Ishima R, Morikawa S, et al. (April 1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". J. Biomol. NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID 7787425. S2CID 36794097.
  2. Arai K, Aimoto S, Morikawa S, Yoshimura S, Ishima R, Imoto T, Miyasaka A, Akasaka K (1995). "Three-dimensional structure of gurmarin, a sweet taste-suppressing polypeptide". J. Biomol. NMR. 5 (3): 297–305. doi:10.1007/BF00211756. PMID 7787425. S2CID 36794097.
This article incorporates text from the public domain Pfam and InterPro: IPR010485


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