HACE1

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HACE1 gene. [4]

HACE1
Identifiers
AliasesHACE1, SPPRS, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
External IDsOMIM: 610876 MGI: 2446110 HomoloGene: 10807 GeneCards: HACE1
Orthologs
SpeciesHumanMouse
Entrez

57531

209462

Ensembl

ENSG00000085382

ENSMUSG00000038822

UniProt

Q8IYU2

Q3U0D9

RefSeq (mRNA)

NM_020771
NM_001321080
NM_001321083
NM_001321084

NM_172473

RefSeq (protein)

NP_766061

Location (UCSC)n/aChr 10: 45.58 – 45.71 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016].

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000038822 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1". Retrieved 2018-07-11.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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