HAGH

Hydroxyacylglutathione hydrolase, mitochondrial is an enzyme that in humans is encoded by the HAGH gene.[5][6][7]

HAGH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHAGH, GLO2, GLX2, GLXII, HAGH1, hydroxyacylglutathione hydrolase
External IDsOMIM: 138760 MGI: 95745 HomoloGene: 3890 GeneCards: HAGH
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p13.3Start1,795,620 bp[1]
End1,827,157 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3029

14651

Ensembl

ENSG00000063854

ENSMUSG00000024158

UniProt

Q16775

Q99KB8

RefSeq (mRNA)

NM_001040427
NM_001286249
NM_005326
NM_001363912
NM_001363914

NM_001159626
NM_024284

RefSeq (protein)

NP_001035517
NP_001273178
NP_005317
NP_001350841
NP_001350843

NP_001153098
NP_077246

Location (UCSC)Chr 16: 1.8 – 1.83 MbChr 17: 24.84 – 24.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000063854 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024158 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Mulley JC, Callen DF (Feb 1987). "New regional localisations for HAGH and PGP on human chromosome 16". Hum Genet. 74 (4): 423–4. doi:10.1007/BF00280498. PMID 3025077. S2CID 19620852.
  6. Honey NK, Shows TB (Apr 1982). "Assignment of the glyoxalase II gene (HAGH) to human chromosome 16". Hum Genet. 58 (4): 358–61. doi:10.1007/bf00282815. PMID 7327557. S2CID 10452468.
  7. "Entrez Gene: HAGH hydroxyacylglutathione hydrolase".

Further reading


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