HEPACAM2

HEPACAM family member 2 is a protein that in humans is encoded by the HEPACAM2 gene. [5]

HEPACAM2
Identifiers
AliasesHEPACAM2, MIKI, HEPACAM family member 2
External IDsOMIM: 614133 MGI: 2141520 HomoloGene: 18724 GeneCards: HEPACAM2
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q21.2Start93,188,534 bp[1]
End93,226,469 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

253012

101202

Ensembl

ENSG00000188175

ENSMUSG00000044156

UniProt

A8MVW5

Q4VAH7

RefSeq (mRNA)

NM_001039372
NM_001288804
NM_001288810
NM_198151
NM_001346642

NM_178899

RefSeq (protein)

NP_001034461
NP_001275733
NP_001275739
NP_001333571
NP_937794

NP_849230

Location (UCSC)Chr 7: 93.19 – 93.23 MbChr 6: 3.46 – 3.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein related to the immunoglobulin superfamily that plays a role in mitosis. Knockdown of this gene results in prometaphase arrest, abnormal nuclear morphology and apoptosis.

Poly(ADP-ribosylation) of the encoded protein promotes its translocation to centrosomes, which may stimulate centrosome maturation. A chromosomal deletion including this gene may be associated with myeloid leukemia and myelodysplastic syndrome in human patients.

References
  1. GRCh38: Ensembl release 89: ENSG00000188175 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044156 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: HEPACAM family member 2". Retrieved 2017-09-13.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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