HIST1H2BG

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BG gene.[5][6][7]

H2BC8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH2BC8, H2B.1A, H2B/a, H2BFA, dJ221C16.8, histone cluster 1, H2bg, histone cluster 1 H2B family member g, HIST1H2BG, H2B clustered histone 8, H2BC10, H2BC7, H2BC6, H2BC4
External IDsOMIM: 602798 MGI: 2448383 HomoloGene: 136770 GeneCards: H2BC8
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.2Start26,215,159 bp[1]
End26,216,692 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8339

319180

Ensembl

ENSG00000273802

ENSMUSG00000069268

UniProt

P62807

P10853

RefSeq (mRNA)

NM_003518

NM_178195

RefSeq (protein)

NP_003517
NP_001368918

Location (UCSC)Chr 6: 26.22 – 26.22 MbChr 13: 23.57 – 23.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000273802 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000069268 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
  6. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  7. "Entrez Gene: HIST1H2BG histone cluster 1, H2bg".

Further reading

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