HIV salivary gland disease

Human immunodeficiency virus salivary gland disease (abbreviated to HIV-SGD,[1] and also termed HIV-associated salivary gland disease),[2] is swelling of the salivary glands and/or xerostomia in individuals infected with human immunodeficiency virus.

Signs and symptoms

HIV-SGD may be the presenting sign of HIV infection.[3] There may also be xerophthalmia (dry eyes) and arthralgia (joint pain), similar to Sjögren syndrome.[3]


HIV-SGD is more prevalent in HIV positive children than HIV positive adults,[4] at about 19% and 1% respectively.[1] Unlike other oral manifestations of HIV/AIDS such as Kaposi sarcoma, oral hairy leukoplakia and oral candidiasis, which decreased following the introduction of highly active antiretroviral therapy (HAART), HIV-SGD has increased.[2]


  1. 1 2 Burket LW; Greenberg MS; Michael Glick; Jonathan A. Ship (2008). Burket's Oral Medicine. PMPH-USA. pp. 207–208. ISBN 978-1-55009-345-2.
  2. 1 2 3 4 Jeffers, L; Webster-Cyriaque, JY (April 2011). "Viruses and salivary gland disease (SGD): lessons from HIV SGD.". Advances in Dental Research. 23 (1): 79–83. doi:10.1177/0022034510396882. PMC 3144046Freely accessible. PMID 21441486.
  3. 1 2 3 Witt RL (1 January 2011). Salivary Gland Diseases: Surgical and Medical Management. Thieme. pp. 60–61. ISBN 978-1-60406-537-4.
  4. Schiødt, M (February 1992). "HIV-associated salivary gland disease: a review.". Oral surgery, oral medicine, and oral pathology. 73 (2): 164–7. doi:10.1016/0030-4220(92)90189-w. PMID 1549310.
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