HM13

Minor histocompatibility antigen H13 is a protein that in humans is encoded by the HM13 gene.[5][6][7]

HM13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHM13, H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1, dJ324O17.1, histocompatibility (minor) 13, histocompatibility minor 13
External IDsOMIM: 607106 MGI: 95886 HomoloGene: 7749 GeneCards: HM13
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.21Start31,514,410 bp[1]
End31,577,923 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

81502

14950

Ensembl

ENSG00000101294

ENSMUSG00000019188

UniProt

Q8TCT9

Q9D8V0

RefSeq (mRNA)

NM_030789
NM_178580
NM_178581
NM_178582

NM_001159551
NM_001159552
NM_001159553
NM_010376

RefSeq (protein)

NP_110416
NP_848695
NP_848696
NP_848697

NP_001153023
NP_001153024
NP_001153025
NP_034506

Location (UCSC)Chr 20: 31.51 – 31.58 MbChr 2: 152.67 – 152.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The minor histocompatibility antigen 13 is a nonamer peptide that originates from a protein encoded by the H13 gene.[8][9] The peptide is generated by the cytosol by the proteasome, enters the endoplasmic reticulum (ER) lumen by the transporter associated with antigen processing (TAP) and is presented on the cell surface on H2-Db major histocompatibility antigen I (MHC I) molecules. The alloreactivity, which leads to transplant rejection in mice, is conferred by Val/Ile polymorphism in the ‘SSV(V/I)GVWYL’ peptide.[10] The orthologue gene in humans is called HM13. If a related polymorphism exists, and if the HM13 serves as a Minor histocompatibility antigen, however, remains to be addressed.

The protein encoded by the M13/HM13 gene is the signal peptide peptidase (SPP), an ER-resident intramembrane protease.[5] SPP localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000101294 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019188 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Weihofen A, Binns K, Lemberg MK, Ashman K, Martoglio B (Jun 2002). "Identification of signal peptide peptidase, a presenilin-type aspartic protease". Science. 296 (5576): 2215–8. doi:10.1126/science.1070925. PMID 12077416. S2CID 45633906.
  6. Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE (Apr 2004). "Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor". J Biol Chem. 279 (15): 15153–60. doi:10.1074/jbc.M309305200. PMID 14704149.
  7. "Entrez Gene: HM13 histocompatibility (minor) 13".
  8. "Entrez Gene: H13 histocompatibility (minor) 13".
  9. Snell GD, Cudkowicz G, Bunker HP (Jun 1967). "Histocompatibility genes of mice. VII. H-13, a new histocompatibility locus in the fifth linkage group". Transplantation. 5 (3): 492–503. doi:10.1097/00007890-196705000-00011. PMID 5340356. S2CID 31345625.
  10. Mendoza LM, Paz P, Zuberi A, Christianson G, Roopenian D, Shastri N (Oct 1997). "Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex". Immunity. 7 (4): 461–72. doi:10.1016/S1074-7613(00)80368-4. PMID 9354467.

Further reading


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