HNRNPLL

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.[5]

HNRNPLL
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like
External IDsOMIM: 611208 MGI: 1919942 HomoloGene: 26701 GeneCards: HNRNPLL
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p22.1Start38,561,969 bp[1]
End38,603,586 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

92906

72692

Ensembl

ENSG00000143889

ENSMUSG00000024095

UniProt

Q8WVV9

Q921F4

RefSeq (mRNA)

NM_001142650
NM_138394

NM_144802

RefSeq (protein)

NP_001136122
NP_612403

NP_659051

Location (UCSC)Chr 2: 38.56 – 38.6 MbChr 17: 80.03 – 80.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000143889 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024095 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like".
  6. Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A (August 2008). "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–91. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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