HOMER3

Homer protein homolog 3 is a protein that in humans is encoded by the HOMER3 gene.[5][6][7]

HOMER3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHOMER3, HOMER-3, VESL3, homer scaffolding protein 3, homer scaffold protein 3
External IDsOMIM: 604800 MGI: 1347359 HomoloGene: 37972 GeneCards: HOMER3
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.11Start18,929,201 bp[1]
End18,941,261 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9454

26558

Ensembl

ENSG00000051128

ENSMUSG00000003573

UniProt

Q9NSC5

Q99JP6

RefSeq (mRNA)

NM_001145721
NM_001145722
NM_001145724
NM_004838

NM_001146153
NM_011984

RefSeq (protein)

NP_001139625
NP_036114

Location (UCSC)Chr 19: 18.93 – 18.94 MbChr 8: 70.28 – 70.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein may be involved in cell growth.[7]

Interactions

HOMER3 has been shown to interact with TRPC1[8] and RYR1.[9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000051128 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003573 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Soloviev MM, Ciruela F, Chan WY, McIlhinney RA (Feb 2000). "Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing". Journal of Molecular Biology. 295 (5): 1185–200. doi:10.1006/jmbi.1999.3436. PMID 10653696.
  6. Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (Oct 1998). "Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors". Neuron. 21 (4): 717–26. doi:10.1016/S0896-6273(00)80589-9. PMID 9808459. S2CID 2851554.
  7. "Entrez Gene: HOMER3 homer homolog 3 (Drosophila)".
  8. Yuan JP, Kiselyov K, Shin DM, Chen J, Shcheynikov N, Kang SH, Dehoff MH, Schwarz MK, Seeburg PH, Muallem S, Worley PF (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell. 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. PMID 14505576. S2CID 10552676.
  9. Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, Pessah IN (Nov 2002). "Homer regulates gain of ryanodine receptor type 1 channel complex". The Journal of Biological Chemistry. 277 (47): 44722–30. doi:10.1074/jbc.M207675200. PMID 12223488.

Further reading

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