HSPB6

HSPB6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JUS, 4JUT
Identifiers
Aliases	HSPB6, HEL55, Hsp20, PPP1R91, heat shock protein family B (small) member 6
External IDs	OMIM: 610695 MGI: 2685325 HomoloGene: 36931 GeneCards: HSPB6
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	35,758,079 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	30,555,443 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• structural constituent of eye lens; • protein homodimerization activity; • GO:0001948 protein binding; • unfolded protein binding; • chaperone binding;
Cellular component	• cell nucleus; • cytoplasm; • extracellular region;
Biological process	• regulation of muscle contraction; • negative regulation of cardiac muscle cell apoptotic process; • positive regulation of angiogenesis; • chaperone-mediated protein folding;
	Sources:Amigo / QuickGO
Orthologs
	126393
	243912
	ENSG00000004776
	ENSMUSG00000036854
	O14558
	Q5EBG6
	NM_144617
	NM_001012401; NM_001364179
	NP_653218
	NP_001012401; NP_001351108
	Wikidata
View/Edit Human	View/Edit Mouse

Heat shock protein beta-6 is a protein that in humans is encoded by the HSPB6 gene.[5][6][7]

HSPB6 also known as hsp20 is a 17-kDa member of the small heat shock family of proteins. HSPB6 was first identified in 1994 when it was isolated from rat and human skeletal muscle as a complex with HSPB1 (also known as HSP27) and HSPB5 (also known as αB-crystallin).[8]

HSPB6 is expressed in multiple tissues; however, HSPB6 is most highly and constitutively expressed in different types of muscle including vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle and skeletal muscle. HSPB6 has specific functions for vasodilation, platelet function, and insulin resistance[9] and in smooth and cardiac muscle.[10][11]

References

GRCh38: Ensembl release 89: ENSG00000004776 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000036854 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW (Jun 2003). "The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10". Cell Stress Chaperones. 8 (1): 53–61. doi:10.1379/1466-1268(2003)8<53:THGECS>2.0.CO;2. PMC 514853. PMID 12820654.
Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004). "Some properties of human small heat shock protein Hsp20 (HspB6)". Eur J Biochem. 271 (2): 291–302. doi:10.1046/j.1432-1033.2003.03928.x. PMID 14717697.
"Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6".
Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T (May 1994). "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin". J. Biol. Chem. 269 (21): 15302–9. PMID 8195168.
Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM (Jan 2010). "The small heat shock protein, HSPB6, in muscle function and disease". Cell Stress Chaperones. 15 (1): 1–11. doi:10.1007/s12192-009-0127-8. PMC 2866971. PMID 19568960.
Salinthone S, Tyagi M, Gerthoffer WT (July 2008). "Small heat shock proteins in smooth muscle". Pharmacol. Ther. 119 (1): 44–54. doi:10.1016/j.pharmthera.2008.04.005. PMC 2581864. PMID 18579210.
Fan GC, Chu G, Kranias EG (May 2005). "Hsp20 and its cardioprotection". Trends Cardiovasc. Med. 15 (4): 138–41. doi:10.1016/j.tcm.2005.05.004. PMID 16099377.

External links

Overview of all the structural information available in the PDB for UniProt: O14558 (Heat shock protein beta-6) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000004776 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036854 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12820654-5] Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW (Jun 2003). "The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10". Cell Stress Chaperones. 8 (1): 53–61. doi:10.1379/1466-1268(2003)8<53:THGECS>2.0.CO;2. PMC 514853. PMID 12820654.

[pmid14717697-6] Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004). "Some properties of human small heat shock protein Hsp20 (HspB6)". Eur J Biochem. 271 (2): 291–302. doi:10.1046/j.1432-1033.2003.03928.x. PMID 14717697.

[entrez-7] "Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6".

[pmid8195168-8] Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T (May 1994). "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin". J. Biol. Chem. 269 (21): 15302–9. PMID 8195168.

[PMC2866971-9] Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM (Jan 2010). "The small heat shock protein, HSPB6, in muscle function and disease". Cell Stress Chaperones. 15 (1): 1–11. doi:10.1007/s12192-009-0127-8. PMC 2866971. PMID 19568960.

[pmid18579210-10] Salinthone S, Tyagi M, Gerthoffer WT (July 2008). "Small heat shock proteins in smooth muscle". Pharmacol. Ther. 119 (1): 44–54. doi:10.1016/j.pharmthera.2008.04.005. PMC 2581864. PMID 18579210.

[pmid16099377-11] Fan GC, Chu G, Kranias EG (May 2005). "Hsp20 and its cardioprotection". Trends Cardiovasc. Med. 15 (4): 138–41. doi:10.1016/j.tcm.2005.05.004. PMID 16099377.

HSPB6

References

Further reading

External links