Hiroshi Maeda (chemist)

Hiroshi Maeda (前田浩, Maeda Hiroshi, born December 22, 1938), Japanese pharmacologist and chemist. He is known for his discovery of EPR effect. He has published more than 450 papers in reputed journals. H-index of 89 in 2014 by Thomson Reuters.

Hiroshi Maeda
Born
前田 浩

(1938-12-22) December 22, 1938
Hyōgo Prefecture, Japan
NationalityJapan
Alma materTohoku University
University of California, Davis
Known forEPR effect
AwardsPrincess Takamatsu Cancer Research Fund Prizes
Clarivate Citation Laureates (2016)
Scientific career
FieldsChemistry
InstitutionsSojo University
Kumamoto University
Harvard University

Education and career

Maeda studied at Tohoku University with a bachelor's degree in 1962, at the University of California, Davis with a master's degree in 1964, and a doctorate in 1967 at Tohoku. He was a post-doctoral at the Sidney Farber Cancer Institute of Harvard University from 1967 to 1971, he also acquired the medical doctorate there.

From 1971 to 1980 he was an assistant professor at Kumamoto University and became a professor from 1980.

Research

Maeda developed the neocarzinostatin "SMANCS" with a copolymer of styrene and maleic acid in 1979. Afterward, Maeda and his student Yasuhiro Matsumura discovered the Enhanced permeability and retention effect (ERP effect) of macromolecular drugs in 1986, which laid an important foundation for the cancer-targeted therapy (CAncer Stromal Targeting; CAST).[1]

Recognition

Maeda was awarded Princess Takamatsu Cancer Research Fund Prizes, Commemorative Gold Medal of E.K.Frey-E.Werle, Life Time Achievement Award of Royal Pharmaceutical Society, CRS College of Fellows Award, Nagai Innovation Award for Outstanding Achievement (2013), and Clarivate Citation Laureates (2016).[2]

He is also a member of Controlled Release Society.

References
  1. Matsumura, Y; Maeda, H (1986). "A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs". Cancer Research. 46 (12): 6387–6392. PMID 2946403. Retrieved 2016-09-29.
  2. 前田 浩 Hiroshi Maeda | Chem-Station (ケムステ)
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