Homocysteine desulfhydrase
In enzymology, a homocysteine desulfhydrase (EC 4.4.1.2) is an enzyme that catalyzes the chemical reaction
- L-homocysteine + H2O hydrogen sulfide + NH3 + 2-oxobutanoate
| homocysteine desulfhydrase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.4.1.2 | ||||||||
| CAS number | 9024-41-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are L-homocysteine and H2O, whereas its 3 products are hydrogen sulfide, NH3, and 2-oxobutanoate.
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-homocysteine hydrogen-sulfide-lyase (deaminating 2-oxobutanoate-forming). Other names in common use include homocysteine desulfurase, L-homocysteine hydrogen-sulfide-lyase, and (deaminating). This enzyme participates in nitrogen metabolism and sulfur metabolism. It employs one cofactor, pyridoxal phosphate.
References
- Kallio RE (September 1951). "Function of pyridoxal phosphate in desulfhydrase systems of Proteus morganii". The Journal of Biological Chemistry. 192 (1): 371–7. PMID 14917685.
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