Homophthalic acid

Homophthalic acid is a dicarboxylic acid with the formula C6H4(CO2H)CH2CO2H. It is a colorless solid. The compounds can be prepared by the Willgerodt reaction from 2-acetylbenzoic acid.[3]

Homophthalic acid
Names
IUPAC name
2-(Carboxymethyl)benzoic acid
Other names
α-Carboxy-o-toluic acid
Carboxyphenyl acetic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.001.740
EC Number
  • 66643
Properties
C9H8O4
Molar mass 180.159 g·mol−1
Appearance Off-white to light yellow or pale green
Melting point 181 °C (358 °F; 454 K) [2]
Hazards
GHS pictograms
GHS Signal word Warning
H315, H319, H335
P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

One of the uses is in the preparation of the NSAID tesicam.

References

  1. Index
  2. Homophthalic Acid | C9H8O4 | Chemspider
  3. Schwenk, Erwin; Papa, Domenick (1946). "Preparation of Aryl Aliphatic Acids by the Modified Willgerodt Reaction". The Journal of Organic Chemistry. 11 (6): 798–802. doi:10.1021/jo01176a023. PMID 20282506.


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