IFI30

IFI30
Identifiers
Aliases	IFI30, GILT, IFI-30, IP30, IP-30, lysosomal thiol reductase, IFI30 lysosomal thiol reductase
External IDs	OMIM: 604664 MGI: 2137648 HomoloGene: 38171 GeneCards: IFI30
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	18,178,117 bp[1]
Gene ontology
Molecular function	• oxidoreductase activity; • GO:0001948 protein binding; • oxidoreductase activity, acting on a sulfur group of donors;
Cellular component	• extracellular region; • cell junction; • lysosomal lumen; • intracellular membrane-bounded organelle; • lysosome; • cytosol;
Biological process	• oxidation-reduction process; • interferon-gamma-mediated signaling pathway; • immune system process; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • antigen processing and presentation of exogenous peptide antigen via MHC class I;
	Sources:Amigo / QuickGO
Orthologs
	10437
	65972
	ENSG00000216490
	ENSMUSG00000031838
	P13284
	Q9ESY9
	NM_006332
	NM_023065
	NP_006323
	NP_075552
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene.[4][5][6]

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.[6]

References

GRCh38: Ensembl release 89: ENSG00000216490 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. PMID 3136170.
Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. doi:10.1073/pnas.97.2.745. PMC 15401. PMID 10639150.
"Entrez Gene: IFI30 interferon, gamma-inducible protein 30".

Csányi E (1977). "[Endre Kótai; 1914-1976]". Magyar traumatológia, orthopaedia és helyreállító sebészet. 20 (1): 1. PMID 16170.
Sabin NM (1977). "Letters to the editors". The Journal of the Wisconsin Dental Association. 52 (1): 9. PMID 1069150.
Phan UT, Arunachalam B, Cresswell P (2000). "Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action". J. Biol. Chem. 275 (34): 25907–14. doi:10.1074/jbc.M003459200. PMID 10852914.
Phan UT, Maric M, Dick TP, Cresswell P (2001). "Multiple species express thiol oxidoreductases related to GILT". Immunogenetics. 53 (4): 342–6. doi:10.1007/s002510100323. PMID 11491538. S2CID 848449.
Haque MA, Li P, Jackson SK, et al. (2002). "Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes". J. Exp. Med. 195 (10): 1267–77. doi:10.1084/jem.20011853. PMC 2193747. PMID 12021307.
Phan UT, Lackman RL, Cresswell P (2002). "Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12298–303. doi:10.1073/pnas.182430499. PMC 129439. PMID 12198183.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000216490 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3136170-4] Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. PMID 3136170.

[pmid10639150-5] Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. doi:10.1073/pnas.97.2.745. PMC 15401. PMID 10639150.

[entrez-6] "Entrez Gene: IFI30 interferon, gamma-inducible protein 30".

IFI30

References

Further reading