IFIT2

Interferon-induced protein with tetratricopeptide repeats 2 or IFIT2 is a protein found in humans which is encoded by the IFIT2 gene.[5][6][7]

IFIT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIFIT2, G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42, interferon induced protein with tetratricopeptide repeats 2
External IDsOMIM: 147040 MGI: 99449 HomoloGene: 1187 GeneCards: IFIT2
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q23.31Start89,283,694 bp[1]
End89,309,271 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3433

15958

Ensembl

ENSG00000119922

ENSMUSG00000045932

UniProt

P09913

Q64112

RefSeq (mRNA)

NM_001547

NM_008332
NM_001355262

RefSeq (protein)

NP_001538

NP_032358
NP_001342191

Location (UCSC)Chr 10: 89.28 – 89.31 MbChr 19: 34.55 – 34.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance

IFIT2 may play a role in prevention of tumor progression.[8] Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[9] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000119922 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000045932 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C (Nov 1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat Cell Mol Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763. S2CID 42406993.
  6. Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. doi:10.1016/0014-5793(88)80724-5. PMID 3360121. S2CID 22937671.
  7. "Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2".
  8. Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC (2008). "IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma". Mol. Cancer Res. 6 (9): 1431–9. doi:10.1158/1541-7786.MCR-08-0141. PMID 18819931.
  9. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602. S2CID 24986454.

Further reading


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