IKZF4

Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.[5][6]

IKZF4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIKZF4, EOS, ZNFN1A4, IKAROS family zinc finger 4
External IDsOMIM: 606239 MGI: 1343139 HomoloGene: 69103 GeneCards: IKZF4
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q13.2Start56,007,659 bp[1]
End56,038,435 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64375

22781

Ensembl

ENSG00000123411

ENSMUSG00000002578

UniProt

Q9H2S9

Q8C208

RefSeq (mRNA)

NM_022465
NM_001351089
NM_001351090
NM_001351091
NM_001351092

NM_011772
NM_001358536
NM_001358537

RefSeq (protein)

NP_071910
NP_001338018
NP_001338019
NP_001338020
NP_001338021

NP_035902
NP_001345465
NP_001345466

Location (UCSC)Chr 12: 56.01 – 56.04 MbChr 10: 128.63 – 128.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM][6]

Interactions

IKZF4 has been shown to interact with CTBP1[7] and IKZF1.[5][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000123411 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000002578 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Perdomo J, Holmes M, Chong B, Crossley M (Jan 2001). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". J Biol Chem. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
  6. "Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)".
  7. Perdomo, José; Crossley Merlin (Dec 2002). "The Ikaros family protein Eos associates with C-terminal-binding protein corepressors". Eur. J. Biochem. Germany. 269 (23): 5885–92. doi:10.1046/j.1432-1033.2002.03313.x. ISSN 0014-2956. PMID 12444977.
  8. Honma, Y; Kiyosawa H; Mori T; Oguri A; Nikaido T; Kanazawa K; Tojo M; Takeda J; Tanno Y; Yokoya S; Kawabata I; Ikeda H; Wanaka A (Mar 1999). "Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system". FEBS Lett. NETHERLANDS. 447 (1): 76–80. doi:10.1016/S0014-5793(99)00265-3. ISSN 0014-5793. PMID 10218586. S2CID 28898354.

Further reading


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