INPP5B

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.[5][6]

INPP5B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesINPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDsOMIM: 147264 MGI: 103257 HomoloGene: 69021 GeneCards: INPP5B
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p34.3Start37,860,697 bp[1]
End37,947,057 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3633

16330

Ensembl

ENSG00000204084

ENSMUSG00000028894

UniProt

P32019

Q8K337

RefSeq (mRNA)

NM_001297434
NM_005540
NM_001350227
NM_001350228

NM_008385

RefSeq (protein)

NP_032411

Location (UCSC)Chr 1: 37.86 – 37.95 MbChr 4: 124.74 – 124.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000204084 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028894 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ross TS, Jefferson AB, Mitchell CA, Majerus PW (Dec 1991). "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase". J Biol Chem. 266 (30): 20283–9. doi:10.1016/S0021-9258(18)54920-6. PMID 1718960.
  6. "Entrez Gene: INPP5B inositol polyphosphate-5-phosphatase, 75kDa".

Further reading


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