INPP5B

Type II inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5B gene.[5][6]

INPP5B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MTC, 3N9V, 4CML, 5A7J, 5A7I
Identifiers
Aliases	INPP5B, 5PTase, inositol polyphosphate-5-phosphatase B
External IDs	OMIM: 147264 MGI: 103257 HomoloGene: 69021 GeneCards: INPP5B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 37,860,697 bp[1] End 37,947,057 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 D2.2|4 57.89 cM Start 124,741,850 bp[2] End 124,801,511 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • metal ion binding • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity • GO:0001948 protein binding • hydrolase activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • inositol-1,4,5-trisphosphate 5-phosphatase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity • inositol phosphate phosphatase activity Cellular component • integral component of membrane • cytosol • endosome • phagocytic vesicle membrane • Golgi apparatus • early endosome membrane • membrane • cell membrane • cytoplasmic vesicle • endoplasmic reticulum-Golgi intermediate compartment • cytoplasm Biological process • flagellated sperm motility • in utero embryonic development • inositol phosphate metabolic process • regulation of protein processing • phosphatidylinositol dephosphorylation • spermatogenesis • regulation of small GTPase mediated signal transduction • signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3633	16330
Ensembl	ENSG00000204084	ENSMUSG00000028894
UniProt	P32019	Q8K337
RefSeq (mRNA)	NM_001297434 NM_005540 NM_001350227 NM_001350228	NM_008385
RefSeq (protein)	NP_001284363 NP_005531 NP_001337156 NP_001337157 NP_001352749 NP_001352750 NP_001352751 NP_001352752 NP_001352753 NP_001352754	NP_032411
Location (UCSC)	Chr 1: 37.86 – 37.95 Mb	Chr 4: 124.74 – 124.8 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]