ISG20

ISG20
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WLJ
Identifiers
Aliases	ISG20, CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20
External IDs	OMIM: 604533 MGI: 1928895 HomoloGene: 31081 GeneCards: ISG20
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	88,656,483 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	78,920,396 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• 3'-5'-exoribonuclease activity; • single-stranded DNA 3'-5' exodeoxyribonuclease activity; • exoribonuclease II activity; • metal ion binding; • U3 snoRNA binding; • U2 snRNA binding; • RNA binding; • nucleic acid binding; • U1 snRNA binding; • nuclease activity; • exonuclease activity; • hydrolase activity;
Cellular component	• cytoplasm; • Cajal body; • PML body; • nucleoplasm; • nucleolus; • cell nucleus;
Biological process	• immune system process; • response to virus; • RNA catabolic process; • negative regulation of viral genome replication; • DNA catabolic process, exonucleolytic; • defense response to virus; • type I interferon signaling pathway; • rRNA processing; • innate immune system; • cellular proliferation; • RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	3669
	57444
	ENSG00000172183
	ENSMUSG00000039236
	Q96AZ6
	Q9JL16
NM_001303233; NM_001303234; NM_001303235; NM_001303236; NM_001303237;
	NM_002201
	NM_001113527; NM_001291220; NM_001291221; NM_020583
NP_001290162; NP_001290163; NP_001290164; NP_001290165; NP_001290166;
	NP_002192
	NP_001106999; NP_001278149; NP_001278150; NP_065608
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000172183 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000039236 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A, Mechti N (Aug 1997). "Molecular cloning of a new interferon-induced PML nuclear body-associated protein". The Journal of Biological Chemistry. 272 (31): 19457–63. doi:10.1074/jbc.272.31.19457. PMID 9235947.
Mattei MG, Tissot C, Gongora C, Mechti N (Jun 1998). "Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization". Cytogenetics and Cell Genetics. 79 (3–4): 286–7. doi:10.1159/000134745. PMID 9605874.
"Entrez Gene: ISG20 interferon stimulated exonuclease gene 20kDa".

Pentecost BT (Jan 1998). "Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus". The Journal of Steroid Biochemistry and Molecular Biology. 64 (1–2): 25–33. doi:10.1016/S0960-0760(97)00140-4. PMID 9569007.
Nguyen LH, Espert L, Mechti N, Wilson DM (Jun 2001). "The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro". Biochemistry. 40 (24): 7174–9. doi:10.1021/bi010141t. PMID 11401564.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (Feb 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nature Medicine. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
Espert L, Degols G, Gongora C, Blondel D, Williams BR, Silverman RH, Mechti N (May 2003). "ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses". The Journal of Biological Chemistry. 278 (18): 16151–8. doi:10.1074/jbc.M209628200. PMID 12594219.
Horio T, Murai M, Inoue T, Hamasaki T, Tanaka T, Ohgi T (Nov 2004). "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease". FEBS Letters. 577 (1–2): 111–6. doi:10.1016/j.febslet.2004.09.074. PMID 15527770.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172183 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039236 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9235947-5] Gongora C, David G, Pintard L, Tissot C, Hua TD, Dejean A, Mechti N (Aug 1997). "Molecular cloning of a new interferon-induced PML nuclear body-associated protein". The Journal of Biological Chemistry. 272 (31): 19457–63. doi:10.1074/jbc.272.31.19457. PMID 9235947.

[pmid9605874-6] Mattei MG, Tissot C, Gongora C, Mechti N (Jun 1998). "Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization". Cytogenetics and Cell Genetics. 79 (3–4): 286–7. doi:10.1159/000134745. PMID 9605874.

[entrez-7] "Entrez Gene: ISG20 interferon stimulated exonuclease gene 20kDa".

ISG20

References

Further reading