ITIH2

Inter-alpha-trypsin inhibitor heavy chain H2 is a protein that in humans is encoded by the ITIH2 gene.[5][6][7]

ITIH2
Identifiers
AliasesITIH2, H2P, SHAP, inter-alpha-trypsin inhibitor heavy chain 2
External IDsOMIM: 146640 MGI: 96619 HomoloGene: 1668 GeneCards: ITIH2
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p14Start7,703,316 bp[1]
End7,749,520 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3698

16425

Ensembl

ENSG00000151655

ENSMUSG00000037254

UniProt

P19823

Q61703

RefSeq (mRNA)

NM_002216

NM_010582

RefSeq (protein)

NP_002207

NP_034712

Location (UCSC)Chr 10: 7.7 – 7.75 MbChr 2: 10.09 – 10.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It is known to contain a Gla domain, and thus be dependent for production on post translational modification requiring vitamin K. Its function is also presumably dependent on calcium ions.

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000151655 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037254 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992). "Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily". Genomics. 14 (1): 83–8. doi:10.1016/S0888-7543(05)80287-3. PMID 1385302.
  6. Jean L, Risler JL, Nagase T, Coulouarn C, Nomura N, Salier JP (May 1999). "The nuclear protein PH5P of the inter-alpha-inhibitor superfamily: a missing link between poly(ADP-ribose)polymerase and the inter-alpha-inhibitor family and a novel actor of DNA repair?". FEBS Lett. 446 (1): 6–8. doi:10.1016/S0014-5793(99)00173-8. PMID 10100603. S2CID 84807160.
  7. "Entrez Gene: ITIH2 inter-alpha (globulin) inhibitor H2".

Further reading


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