Ipratropium bromide/salbutamol

Ipratropium bromide/salbutamol, sold under the brand name Combivent among others, is a combination medication used to treat chronic obstructive pulmonary disease (COPD).[1][2] It contains ipratropium (an anticholinergic) and salbutamol (albuterol, a β2-adrenergic agonist).[1] It is taken by inhalation.[3]

Ipratropium bromide/salbutamol
Combination of
Ipratropium bromideMuscarinic antagonist
SalbutamolShort-acting β2-adrenergic agonist
Clinical data
Trade namesCombivent, DuoNeb, Breva, others
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601063
License data
Routes of
administration		Inhalation
ATC code
Legal status
Legal status
  • AU: S3 (Pharmacist only)
  • UK: POM (Prescription only)
  • US: ℞-only
  (verify)

Common side effects include sore throat, muscle cramps, and nausea.[1] Other side effects may include bronchospasm, allergic reactions, and upper respiratory tract infections.[1] Safety in pregnancy is unclear.[4] Each medication typically decreases bronchospasm and does so via different mechanisms.[1]

The combination was approved for medical use in the United States in 1996.[3] It is available as a generic medication.[2] In 2017, it was the 172nd most commonly prescribed medication in the United States, with more than three million prescriptions.[5][6]

Society and culture

Since Combivent contains a chlorofluorocarbon-based propellant, it is being phased out in European Union countries. Chloroflourocarbons (CFC) are attributed to depletion of the ozone layer.

References
  1. "DailyMed - ipratropium bromide and albuterol sulfate inhalant". dailymed.nlm.nih.gov. Retrieved 18 April 2019.
  2. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 247. ISBN 9780857113382.
  3. "Ipratropium and Albuterol - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 18 April 2019.
  4. "Albuterol / ipratropium Use During Pregnancy". Drugs.com. Retrieved 19 April 2019.
  5. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  6. "Albuterol Sulfate; Ipratropium Bromide - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
  • DailyMed
  • Consumer Medication Information from PubMed
  • National Asthma Education and Prevention Program Expert Panel 3. Expert panel report 3: guidelines for the diagnosis and management of asthma. Bethesda (MD): National Institutes of Health. National Heart, Lung, and Blood Institute; 2007 Aug. NIH Publication No. 07-4051.
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