JAM3

JAM3
Identifiers
Aliases	JAM3, JAM-2, JAM-3, JAM-C, JAMC, junctional adhesion molecule 3
External IDs	OMIM: 606871 MGI: 1933825 HomoloGene: 11338 GeneCards: JAM3
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	134,152,001 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	27,155,421 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein homodimerization activity; • integrin binding; • GO:0001948 protein binding; • protein heterodimerization activity;
Cellular component	• integral component of membrane; • membrane; • cell-cell contact zone; • intercellular junction; • bicellular tight junction; • cell membrane; • desmosome; • Schmidt-Lanterman incisure; • extracellular region; • cell junction; • paranodal junction; • extracellular; • Golgi apparatus; • integral component of plasma membrane;
Biological process	• neutrophil homeostasis; • regulation of neutrophil chemotaxis; • regulation of actin cytoskeleton organization by cell-cell adhesion; • myeloid progenitor cell differentiation; • adaptive immune response; • axon regeneration; • transmission of nerve impulse; • leukocyte migration involved in inflammatory response; • extracellular matrix organization; • cell adhesion; • angiogenesis; • spermatogenesis; • establishment of cell polarity; • spermatid development; • myelination; • cell-matrix adhesion; • cell migration; • leukocyte migration; • cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	83700
	83964
	ENSG00000166086
	ENSMUSG00000031990
	Q9BX67
	Q9D8B7
	NM_032801; NM_001205329
	NM_023277
	NP_001192258; NP_116190
	NP_075766
	Wikidata
View/Edit Human	View/Edit Mouse

Junctional adhesion molecule C is a protein that in humans is encoded by the JAM3 gene.[5]

Gene

This gene is located on the long arm of chromosome 11 (11q25) on the Watson strand. It is 83,077 bases in length. The encoded protein is 310 amino acids long with a predicted molecular weight of 35.02 kiloDaltons.

Function

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family.[5]

Interactions

JAM3 has been shown to interact with PARD3.[6]

Clinical significance

Loss-of-function mutations in this gene cause a rare syndrome - autosomal recessive hemorrhagic destruction of the brain, subependymal calcification and congenital cataracts.[7]

References

GRCh38: Ensembl release 89: ENSG00000166086 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031990 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: JAM3 junctional adhesion molecule 3".
Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
Akawi NA, Canpolat FE, White SM, Quilis-Esquerra J, Sanchez MM, Gamundi MJ, Mochida GH, Walsh CA, Ali BR, Al-Gazali L (December 2012). "Delineation of the Clinical, Molecular and Cellular Aspects of Novel JAM3 Mutations Underlying the Autosomal Recessive Hemorrhagic Destruction of the Brain, Subependymal Calcification and Congenital Cataracts". Hum. Mutat. 34 (3): 498–505. doi:10.1002/humu.22263. PMC 3951164. PMID 23255084.

Muller WA (2003). "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response". Trends Immunol. 24 (6): 327–34. doi:10.1016/S1471-4906(03)00117-0. PMID 12810109.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Arrate MP, Rodriguez JM, Tran TM, et al. (2002). "Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor". J. Biol. Chem. 276 (49): 45826–32. doi:10.1074/jbc.M105972200. PMID 11590146.
Aurrand-Lions M, Johnson-Leger C, Wong C, et al. (2002). "Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members". Blood. 98 (13): 3699–707. doi:10.1182/blood.V98.13.3699. PMID 11739175.
Liang TW, Chiu HH, Gurney A, et al. (2002). "Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3". J. Immunol. 168 (4): 1618–26. doi:10.4049/jimmunol.168.4.1618. PMID 11823489.
Phillips HM, Renforth GL, Spalluto C, et al. (2002). "Narrowing the critical region within 11q24-qter for hypoplastic left heart and identification of a candidate gene, JAM3, expressed during cardiogenesis". Genomics. 79 (4): 475–8. doi:10.1006/geno.2002.6742. PMID 11944976.
Cunningham SA, Rodriguez JM, Arrate MP, et al. (2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. doi:10.1074/jbc.C200331200. PMID 12070135.
Santoso S, Sachs UJ, Kroll H, et al. (2002). "The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1". J. Exp. Med. 196 (5): 679–91. doi:10.1084/jem.20020267. PMC 2194005. PMID 12208882.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ebnet K, Aurrand-Lions M, Kuhn A, et al. (2004). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zen K, Babbin BA, Liu Y, et al. (2005). "JAM-C is a component of desmosomes and a ligand for CD11b/CD18-mediated neutrophil transepithelial migration". Mol. Biol. Cell. 15 (8): 3926–37. doi:10.1091/mbc.E04-04-0317. PMC 491847. PMID 15194813.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Chavakis T, Keiper T, Matz-Westphal R, et al. (2005). "The junctional adhesion molecule-C promotes neutrophil transendothelial migration in vitro and in vivo". J. Biol. Chem. 279 (53): 55602–8. doi:10.1074/jbc.M404676200. PMID 15485832.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Aurrand-Lions M, Lamagna C, Dangerfield JP, et al. (2005). "Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation". J. Immunol. 174 (10): 6406–15. doi:10.4049/jimmunol.174.10.6406. PMID 15879142.
Santoso S, Orlova VV, Song K, et al. (2006). "The homophilic binding of junctional adhesion molecule-C mediates tumor cell-endothelial cell interactions". J. Biol. Chem. 280 (43): 36326–33. doi:10.1074/jbc.M505059200. PMID 16118203.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166086 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031990 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: JAM3 junctional adhesion molecule 3".

[pmid12953056-6] Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.

[pmid23255084-7] Akawi NA, Canpolat FE, White SM, Quilis-Esquerra J, Sanchez MM, Gamundi MJ, Mochida GH, Walsh CA, Ali BR, Al-Gazali L (December 2012). "Delineation of the Clinical, Molecular and Cellular Aspects of Novel JAM3 Mutations Underlying the Autosomal Recessive Hemorrhagic Destruction of the Brain, Subependymal Calcification and Congenital Cataracts". Hum. Mutat. 34 (3): 498–505. doi:10.1002/humu.22263. PMC 3951164. PMID 23255084.