James Manley (disambiguation)
James Manley (born 1974) is a former American football defensive tackle.
James Manley or Manly may also refer to:
- James L. Manley (born 1949), professor of life sciences
- James R. Manley (1782–1851), American physician and professor of obstetrics
- James Manley (wrestler) (born 1958), American professional wrestler, better known by the ring name Jim Powers
- James Manly (born 1932), Canadian politician
- James Manly, sergeant in 3d Armored Cavalry Regiment during Mexican-American War
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