Jorge E. Galán

Jorge Enrique Galán is an Argentinian-American microbiologist who specializes in infectious disease, bacterial pathogenisis including Salmonella.

Jorge E. Galan
EducationPhD Cornell University, 1986

DMV National University of La Plata, Argentina, 1980

Postdoctoral fellow Washington University
OccupationMicrobiologist
Known forType III Protein Secretion Systems, Salmonella & Campylobacter
AwardsRobert Koch Prize

Hans Sigrist Prize

MERIT Award National Institutes of Health

Research

Jorge Galán started his career as an associate professor at SUNY Stony Brook within the Department of Molecular Genetics and Microbiology. In 1998, Galan joined the Yale University Faculty.

Galán now runs the Galán Laboratory at Yale University School of Medicine which studies the 'molecular mechanisms of pathogenesis of Salmonella and Campylobacter.'[1] Galan's lab takes

a multidisciplinary approach that include[s] bacterial genetics, animal models, cell biology, immunology, and structural biology approaches. [They] aim to define the functional and...the atomic interface between these pathogens and their hosts and...to provide the bases for the development of novel prevention and therapeutic strategies to combat infectious diseases that are a global public health concern. [2]

Galan discovered that certain microbes use a molecular machine called a type III secretion system (T3SS, large, needle-like complexes of more than 30 proteins) to infect and replicate within eukaryotic cells. A number of disease-causing Gram-negative bacteria, including Salmonella, Shigella, Yersinia, and Chlamydia, also deploy T3SSs, which makes the system a potential therapeutic target for the next generation of antibiotics.'[3]

Galan’s lab features a cross-disciplinary approach to understanding an essential feature of the pathogenicity of Salmonella and Campylobacter — i.e., the ability of host cell and pathogen to engage in a two-way biochemical interaction, or cross talk. Understanding these mechanism has already led to the identification of several ways to intervene in infections of these bacteria, which cause millions of illnesses each year.[4]

He is the Lucille P. Markey Professor of Microbial Pathogenesis at Yale University.[5]

Awards

MERIT Award National Institutes of Health 2015

Robert Koch Prize, Robert Koch Foundation 2011[6]

Alexander M. Cruickshank Award. Grodon Research Conferences 2010

Senior Scholar Award in Global Infectious Diseases, Ellison Medical Foundation 2004[7][8]

Hans-Sigrist Prize, Hans-Sigrist-Foundation, Berne, Switzerland 2002

MERIT Award, National Institutes of Health 2000

Sinsheimer Scholar in the Biomedical Sciences, Sinsheimer Foundation 1991

Pew Scholar in the Biomedical Sciences, Pew Foundation 1990

References
  1. "The Galán Laboratory". The Galán Laboratory. Retrieved 2020-09-03.
  2. "The Galán Laboratory". The Galán Laboratory. Retrieved 2020-09-03.
  3. Ahmed, Farooq (2016-06-29). "QnAs with Jorge Galán". Proceedings of the National Academy of Sciences. 113 (28): 7686–7687. doi:10.1073/pnas.1608933113. ISSN 0027-8424.
  4. "Microbiologist Jorge Galan wins prestigious Koch Prize". YaleNews. 2011-02-21. Retrieved 2020-09-03.
  5. Yale News for February 21, 2011
  6. "Robert Koch Stiftung - Robert Koch Award". www.robert-koch-stiftung.de. Retrieved 2020-09-03.
  7. "Ellison Medical Foundation". medicine.yale.edu. Retrieved 2020-09-03.
  8. "EMF Senior Scholars elected to National Academy of Sciences | The Lawrence Ellison Foundation". www.ellisonmedicalfoundation.com. Retrieved 2020-09-03.


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