KCTD13

BTB/POZ domain-containing protein KCTD13 is a protein that in humans is encoded by the KCTD13 gene.[5][6]

KCTD13
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKCTD13, BACURD1, PDIP1, POLDIP1, hBACURD1, FKSG86, potassium channel tetramerization domain containing 13
External IDsOMIM: 608947 MGI: 1923739 HomoloGene: 27800 GeneCards: KCTD13
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p11.2Start29,905,012 bp[1]
End29,926,236 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

253980

233877

Ensembl

ENSG00000174943

ENSMUSG00000030685

UniProt

Q8WZ19

Q8BGV7

RefSeq (mRNA)

NM_178863

NM_172747

RefSeq (protein)

NP_849194

NP_766335

Location (UCSC)Chr 16: 29.91 – 29.93 MbChr 7: 126.93 – 126.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

KCTD13 has been shown to interact with PCNA.[5]

Clinical relevance

Mutations in this gene have been associated to abnormalities in brain growth and behaviour.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000174943 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030685 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. He H, Tan CK, Downey KM, So AG (October 2001). "A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 98 (21): 11979–84. Bibcode:2001PNAS...9811979H. doi:10.1073/pnas.221452098. PMC 59753. PMID 11593007.
  6. "Entrez Gene: KCTD13 potassium channel tetramerisation domain containing 13".
  7. Arbogast T, Razaz P, Ellegood J, McKinstry SU, Erdin S, Currall B, et al. (May 2019). "Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions". Human Molecular Genetics. 28 (9): 1474–1486. doi:10.1093/hmg/ddy436. PMC 6489413. PMID 30590535.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human KCTD13
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