KHSRP

KHSRP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HH2, 2HH3, 2JVZ, 2OPU, 2OPV, 4B8T
Identifiers
Aliases	KHSRP, FBP2, FUBP2, KSRP, KH-type splicing regulatory protein, p75
External IDs	OMIM: 603445 MGI: 1336214 HomoloGene: 2734 GeneCards: KHSRP
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	6,424,794 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	57,031,522 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding; • GO:0001948 protein binding; • nucleic acid binding; • mRNA binding; • mRNA 3'-UTR AU-rich region binding; • RNA binding;
Cellular component	• cytoplasm; • cytosol; • membrane; • nucleoplasm; • Stress granule; • cell nucleus; • exosome complex;
Biological process	• mRNA transport; • regulation of transcription, DNA-templated; • mRNA catabolic process; • RNA splicing, via transesterification reactions; • mRNA processing; • transcription, DNA-templated; • regulation of miRNA metabolic process; • RNA splicing; • cellular response to cytokine stimulus; • negative regulation of nitric oxide biosynthetic process; • positive regulation of mRNA catabolic process; • 3'-UTR-mediated mRNA destabilization; • regulation of mRNA stability; • miRNA metabolic process; • transport; • negative regulation of low-density lipoprotein particle clearance;
	Sources:Amigo / QuickGO
Orthologs
	8570
	16549
	ENSG00000088247
	ENSMUSG00000007670
	Q92945
	Q3U0V1
	NM_003685; NM_001366299; NM_001366300
	NM_010613
	NP_003676; NP_001353228; NP_001353229
	NP_034743
	Wikidata
View/Edit Human	View/Edit Mouse

Far upstream element-binding protein 2 is a protein that in humans is encoded by the KHSRP gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000088247 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000007670 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Min H, Turck CW, Nikolic JM, Black DL (May 1997). "A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer". Genes Dev. 11 (8): 1023–36. doi:10.1101/gad.11.8.1023. PMID 9136930.
Davis-Smyth T, Duncan RC, Zheng T, Michelotti G, Levens D (Jan 1997). "The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators". J Biol Chem. 271 (49): 31679–87. doi:10.1074/jbc.271.49.31679. PMID 8940189.
"Entrez Gene: KHSRP KH-type splicing regulatory protein (FUSE binding protein 2)".

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Chou MY, Rooke N, Turck CW, Black DL (1999). "hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells". Mol. Cell. Biol. 19 (1): 69–77. doi:10.1128/MCB.19.1.69. PMC 83866. PMID 9858532.
Ring HZ, Vameghi-Meyers V, Nikolic JM, et al. (1999). "Mapping of the KHSRP gene to a region of conserved synteny on human chromosome 19p13.3 and mouse chromosome 17". Genomics. 56 (3): 350–2. doi:10.1006/geno.1998.5725. PMID 10087204.
Lellek H, Kirsten R, Diehl I, et al. (2000). "Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex". J. Biol. Chem. 275 (26): 19848–56. doi:10.1074/jbc.M001786200. PMID 10781591.
Chou MY, Underwood JG, Nikolic J, et al. (2000). "Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing". Mol. Cell. 5 (6): 949–57. doi:10.1016/S1097-2765(00)80260-9. PMID 10911989.
Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hall MP, Huang S, Black DL (2004). "Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA". Mol. Biol. Cell. 15 (2): 774–86. doi:10.1091/mbc.E03-09-0692. PMC 329392. PMID 14657238.
Gherzi R, Lee KY, Briata P, et al. (2004). "A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery". Mol. Cell. 14 (5): 571–83. doi:10.1016/j.molcel.2004.05.002. PMID 15175153.
Suswam EA, Nabors LB, Huang Y, et al. (2005). "IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR". Int. J. Cancer. 113 (6): 911–9. doi:10.1002/ijc.20675. PMID 15514971. S2CID 33272692.
Wickham L, Benjannet S, Marcinkiewicz E, et al. (2005). "Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". J. Neurochem. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899. S2CID 36799858.
Chou CF, Mulky A, Maitra S, et al. (2006). "Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay". Mol. Cell. Biol. 26 (10): 3695–706. doi:10.1128/MCB.26.10.3695-3706.2006. PMC 1489004. PMID 16648466.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gherzi R, Trabucchi M, Ponassi M, et al. (2007). "The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling". PLOS Biol. 5 (1): e5. doi:10.1371/journal.pbio.0050005. PMC 1702562. PMID 17177604.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088247 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007670 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9136930-5] Min H, Turck CW, Nikolic JM, Black DL (May 1997). "A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer". Genes Dev. 11 (8): 1023–36. doi:10.1101/gad.11.8.1023. PMID 9136930.

[pmid8940189-6] Davis-Smyth T, Duncan RC, Zheng T, Michelotti G, Levens D (Jan 1997). "The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators". J Biol Chem. 271 (49): 31679–87. doi:10.1074/jbc.271.49.31679. PMID 8940189.

[entrez-7] "Entrez Gene: KHSRP KH-type splicing regulatory protein (FUSE binding protein 2)".

KHSRP

References

Further reading