KIF14

KIF14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OZQ
Identifiers
Aliases	KIF14, MKS12, kinesin family member 14, MCPH20
External IDs	OMIM: 611279 MGI: 1098226 HomoloGene: 8916 GeneCards: KIF14
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	200,620,751 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	136,531,511 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• tubulin binding; • nucleotide binding; • protein kinase binding; • ATP-dependent microtubule motor activity, plus-end-directed; • PDZ domain binding; • microtubule motor activity; • microtubule binding; • ATP binding; • GO:0001948 protein binding; • ATPase activity;
Cellular component	• spindle; • cytoplasm; • kinesin complex; • cell nucleus; • membrane; • midbody; • microtubules; • cell membrane; • spindle midzone; • cytoskeleton; • cytosol; • Flemming body;
Biological process	• negative regulation of integrin activation; • cerebral cortex development; • negative regulation of apoptotic process; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • regulation of neuron apoptotic process; • hippocampus development; • regulation of cell growth; • cell division; • substrate adhesion-dependent cell spreading; • regulation of G1/S transition of mitotic cell cycle; • cell proliferation in forebrain; • regulation of G2/M transition of mitotic cell cycle; • cerebellar granular layer structural organization; • olfactory bulb development; • microtubule depolymerization; • proteasome-mediated ubiquitin-dependent protein catabolic process; • cerebellar Purkinje cell layer structural organization; • regulation of myelination; • positive regulation of cell proliferation; • regulation of Rap protein signal transduction; • cerebellar cortex development; • positive regulation of cytokinesis; • negative regulation of neuron apoptotic process; • establishment of protein localization; • regulation of cell migration; • mitotic metaphase plate congression; • regulation of cell maturation; • microtubule-based movement; • activation of protein kinase activity; • regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	9928
	381293
	ENSG00000118193
	ENSMUSG00000041498
	Q15058
	L0N7N1
	NM_001305792; NM_014875
	NM_001081258; NM_001287179
	NP_001292721; NP_055690
	NP_001274108
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF14 is a protein that in humans is encoded by the KIF14 gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000118193 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000041498 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
"Entrez Gene: KIF14 kinesin family member 14".

Nakagawa T, Tanaka Y, Matsuoka E, et al. (1997). "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9654–9. Bibcode:1997PNAS...94.9654N. doi:10.1073/pnas.94.18.9654. PMC 23244. PMID 9275178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Corson TW, Huang A, Tsao MS, Gallie BL (2005). "KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers". Oncogene. 24 (30): 4741–53. doi:10.1038/sj.onc.1208641. PMID 15897902.
Gruneberg U, Neef R, Li X, et al. (2006). "KIF14 and citron kinase act together to promote efficient cytokinesis". J. Cell Biol. 172 (3): 363–72. doi:10.1083/jcb.200511061. PMC 2063646. PMID 16431929.
Corson TW, Gallie BL (2006). "KIF14 mRNA expression is a predictor of grade and outcome in breast cancer". Int. J. Cancer. 119 (5): 1088–94. doi:10.1002/ijc.21954. PMID 16570270.
Carleton M, Mao M, Biery M, et al. (2006). "RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure". Mol. Cell. Biol. 26 (10): 3853–63. doi:10.1128/MCB.26.10.3853-3863.2006. PMC 1488988. PMID 16648480.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Bowles E, Corson TW, Bayani J, et al. (2007). "Profiling genomic copy number changes in retinoblastoma beyond loss of RB1". Genes Chromosomes Cancer. 46 (2): 118–29. doi:10.1002/gcc.20383. PMID 17099872. S2CID 22499766.
Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". J. Proteome Res. 6 (1): 298–305. CiteSeerX 10.1.1.401.4220. doi:10.1021/pr060438j. PMID 17203973.
Corson TW, Zhu CQ, Lau SK, et al. (2007). "KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer". Clin. Cancer Res. 13 (11): 3229–34. doi:10.1158/1078-0432.CCR-07-0393. PMID 17545527.
Madhavan J, Coral K, Mallikarjuna K, et al. (2007). "High expression of KIF14 in retinoblastoma: association with older age at diagnosis". Invest. Ophthalmol. Vis. Sci. 48 (11): 4901–6. doi:10.1167/iovs.07-0063. PMID 17962437.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118193 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041498 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7584044-5] Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

[entrez-6] "Entrez Gene: KIF14 kinesin family member 14".

KIF14

References

Further reading