KIRREL2
Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene.[5][6][7] It is primarily expressed in β cells of the pancreatic islets.[5]
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| Aliases | KIRREL2, FILTRIN, NEPH3, NLG1, kin of IRRE like 2 (Drosophila), kirre like nephrin family adhesion molecule 2 | ||||||||||||||||||||||||
| External IDs | OMIM: 607762 MGI: 2442334 HomoloGene: 35249 GeneCards: KIRREL2 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 19: 35.86 – 35.87 Mb | Chr 7: 30.45 – 30.46 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
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KIRREL2 is a member of the NEPH protein family, which includes NEPH1 (KIRREL) and NEPH2 (KIRREL3). NEPH proteins bind the
References
- GRCh38: Ensembl release 89: ENSG00000126259 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000036915 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Sun C, Kilburn D, Lukashin A, Crowell T, Gardner H, Brundiers R, Diefenbach B, Carulli JP (Jul 2003). "Kirrel2, a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets". Genomics. 82 (2): 130–42. doi:10.1016/S0888-7543(03)00110-1. PMID 12837264.
- Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H (Dec 2002). "Filtrin is a novel member of nephrin-like proteins". Biochem Biophys Res Commun. 300 (2): 364–70. doi:10.1016/S0006-291X(02)02854-1. PMID 12504092.
- "Entrez Gene: KIRREL2 kin of IRRE like 2 (Drosophila)".
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rinta-Valkama J, Aaltonen P, Lassila M, et al. (2007). "Densin and filtrin in the pancreas and in the kidney, targets for humoral autoimmunity in patients with type 1 diabetes". Diabetes Metab. Res. Rev. 23 (2): 119–26. doi:10.1002/dmrr.655. PMID 16741999. S2CID 30494486.
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