KLK6

Kallikrein-6 is a protein that in humans is encoded by the KLK6 gene.[5][6][7][8]

KLK6
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesKLK6, Bssp, Klk7, PRSS18, PRSS9, SP59, hK6, kallikrein related peptidase 6
External IDsOMIM: 602652 MGI: 1343166 HomoloGene: 68279 GeneCards: KLK6
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.41Start50,958,631 bp[1]
End50,969,673 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5653

19144

Ensembl

ENSG00000167755

ENSMUSG00000050063

UniProt

Q92876

n/a

RefSeq (mRNA)

NM_002774
NM_001012964
NM_001012965
NM_001319948
NM_001319949

NM_001164696
NM_001164697
NM_001164698
NM_011177

RefSeq (protein)

NP_001012982
NP_001012983
NP_001306877
NP_001306878
NP_002765

n/a

Location (UCSC)Chr 19: 50.96 – 50.97 MbChr 7: 43.82 – 43.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000167755 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000050063 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamashiro K, Tsuruoka N, Kodama S, Tsujimoto M, Yamamura Y, Tanaka T, Nakazato H, Yamaguchi N (Jan 1997). "Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1350 (1): 11–4. doi:10.1016/s0167-4781(96)00187-x. PMID 9003450.
  6. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins" (PDF). Biological Chemistry. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. S2CID 436200.
  7. Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biological Chemistry. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. S2CID 83910246.
  8. "Entrez Gene: KLK6 kallikrein-related peptidase 6".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: S01.236
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