Keratan sulfotransferase
In enzymology, a keratan sulfotransferase (EC 2.8.2.21) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + keratan adenosine 3',5'-bisphosphate + keratan 6'-sulfate
| keratan sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.21 | ||||||||
| CAS number | 62168-79-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and keratan, whereas its two products are adenosine 3',5'-bisphosphate and keratan 6'-sulfate.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:keratan 6'-sulfotransferase. Other names in common use include 3'-phosphoadenylyl keratan sulfotransferase, keratan sulfate sulfotransferase, and 3'-phosphoadenylylsulfate:keratan sulfotransferase.
References
- Ruter ER, Kresse H (1984). "Partial purification and characterization of 3'-phosphoadenylylsulfate:keratan sulfate sulfotransferases". J. Biol. Chem. 259 (19): 11771–6. PMID 6592165.
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