L-amino-acid alpha-ligase

In enzymology, an L-amino-acid alpha-ligase (EC 6.3.2.28) is an enzyme that catalyzes the chemical reaction

ATP + an L-amino acid + an L-amino acid ADP + phosphate + L-aminoacyl-L-amino acid
L-amino-acid alpha-ligase
Identifiers
EC number6.3.2.28
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Thus, the two substrates of this enzyme are ATP and L-amino acid, whereas its 3 products are ADP, phosphate, and L-aminoacyl-L-amino acid.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-amino acid:L-amino acid ligase (ADP-forming). Other names in common use include L-amino acid alpha-ligase, bacilysin synthetase, YwfE, and L-amino acid ligase.

References

    • Tabata K, Ikeda H, Hashimoto S (2005). "ywfE in Bacillus subtilis codes for a novel enzyme, L-amino acid ligase". J. Bacteriol. 187 (15): 5195–202. doi:10.1128/JB.187.15.5195-5202.2005. PMC 1196041. PMID 16030213.


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