LCTL

LCTL
Identifiers
Aliases	LCTL, KLG, KLPH, lactase like
External IDs	OMIM: 617060 MGI: 2183549 HomoloGene: 70710 GeneCards: LCTL
Gene location (Human)
Chr.	Chromosome 15 (human)[1]
End	66,565,979 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	64,138,118 bp[2]
Gene ontology
Molecular function	• hydrolase activity, hydrolyzing O-glycosyl compounds; • beta-glucosidase activity;
Cellular component	• integral component of membrane; • endoplasmic reticulum membrane; • brush border; • membrane; • endoplasmic reticulum;
Biological process	• glycosyl compound metabolic process; • carbohydrate metabolic process; • lens morphogenesis in camera-type eye; • visual perception; • response to stimulus;
	Sources:Amigo / QuickGO
Orthologs
	197021
	235435
	ENSG00000188501
	ENSMUSG00000032401
	Q6UWM7
	Q8K1F9
	NM_001278562; NM_207338
	NM_145835
	NP_001265491; NP_997221
	NP_665834
	Wikidata
View/Edit Human	View/Edit Mouse

Lactase-like is a protein that in humans is encoded by the LCTL gene.[5] Lactase-like is a glycosidase enzyme.

Function

This gene encodes a member of family 1 glycosidases. Glycosidases are enzymes that hydrolyze glycosidic bonds and are classified into families based on primary amino acid sequence. Most members of family 1 have two conserved glutamic acid residues, which are required for enzymatic activity. The mouse ortholog of this protein has been characterized and has a domain structure of an N-terminal signal peptide, glycosidase domain, transmembrane domain, and a short cytoplasmic tail. It lacks one of the conserved glutamic acid residues important for catalysis, and its function remains to be determined (PMID: 12084582). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

References

GRCh38: Ensembl release 89: ENSG00000188501 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032401 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Lactase-like". Retrieved 2013-09-25.

Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE (December 2011). "Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells". The Journal of Biological Chemistry. 286 (50): 43294–300. doi:10.1074/jbc.M111.267641. PMC 3234855. PMID 22020932.
Mian IS (June 1998). "Sequence, structural, functional, and phylogenetic analyses of three glycosidase families". Blood Cells, Molecules & Diseases. 24 (2): 83–100. doi:10.1006/bcmd.1998.9998. PMID 9779294.
Ito S, Fujimori T, Hayashizaki Y, Nabeshima Y (July 2002). "Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1576 (3): 341–5. doi:10.1016/S0167-4781(02)00281-6. PMID 12084582.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188501 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032401 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Lactase-like". Retrieved 2013-09-25.

LCTL

Function

References

Further reading