LPIN1

Lipin-1 is a protein that in humans is encoded by the LPIN1 gene.[5][6][7][8]

LPIN1
Identifiers
AliasesLPIN1, PAP1, lipin 1
External IDsOMIM: 605518 MGI: 1891340 HomoloGene: 9266 GeneCards: LPIN1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p25.1Start11,677,595 bp[1]
End11,827,409 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23175

14245

Ensembl

ENSG00000134324

ENSMUSG00000020593

UniProt

Q14693

Q91ZP3

RefSeq (mRNA)

NM_001130412
NM_015763
NM_172950
NM_001355598

RefSeq (protein)

NP_001123884
NP_056578
NP_766538
NP_001342527

Location (UCSC)Chr 2: 11.68 – 11.83 MbChr 12: 16.54 – 16.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Lipin-1 has phosphatidate phosphatase activity.[9][10][11] The nuclear localization of Lipin 1 is regulated by the mammalian Target Of Rapamycin protein kinase and links mTORC1 activity to the regulation of Sterol regulatory element-binding proteins (SREBP)-dependent gene transcription.[12][13][14]

Clinical significance

This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.[8][12]

References

  1. GRCh38: Ensembl release 89: ENSG00000134324 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020593 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Péterfy M, Phan J, Xu P, Reue K (January 2001). "Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin". Nature Genetics. 27 (1): 121–4. doi:10.1038/83685. PMID 11138012. S2CID 35168517.
  6. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (February 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  7. Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC, Kelly DP (September 2006). "Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway". Cell Metabolism. 4 (3): 199–210. doi:10.1016/j.cmet.2006.08.005. PMID 16950137.
  8. "Entrez Gene: LPIN1 lipin 1".
  9. Han GS, Wu WI, Carman GM (April 2006). "The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme". The Journal of Biological Chemistry. 281 (14): 9210–8. doi:10.1074/jbc.M600425200. PMC 1424669. PMID 16467296.
  10. Donkor J, Sariahmetoglu M, Dewald J, Brindley DN, Reue K (February 2007). "Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns". The Journal of Biological Chemistry. 282 (6): 3450–7. doi:10.1074/jbc.M610745200. PMID 17158099.
  11. Harris TE, Huffman TA, Chi A, Shabanowitz J, Hunt DF, Kumar A, Lawrence JC (January 2007). "Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1". The Journal of Biological Chemistry. 282 (1): 277–86. doi:10.1074/jbc.M609537200. PMID 17105729.
  12. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM (August 2011). "mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway". Cell. 146 (3): 408–20. doi:10.1016/j.cell.2011.06.034. PMC 3336367. PMID 21816276.
  13. Kennedy BK, Lamming DW (June 2016). "The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging". Cell Metabolism. 23 (6): 990–1003. doi:10.1016/j.cmet.2016.05.009. PMC 4910876. PMID 27304501.
  14. Laplante M, Sabatini DM (April 2013). "Regulation of mTORC1 and its impact on gene expression at a glance". Journal of Cell Science. 126 (Pt 8): 1713–9. doi:10.1242/jcs.125773. PMC 3678406. PMID 23641065.

Further reading


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