LSM8

U6 snRNA-associated Sm-like protein LSm8 is a protein that in humans is encoded by the LSM8 gene.[5][6]

LSM8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLSM8, NAA38, LSM8 homolog, U6 small nuclear RNA associated
External IDsOMIM: 607288 MGI: 1923772 HomoloGene: 9419 GeneCards: LSM8
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q31.31Start118,184,144 bp[1]
End118,204,035 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51691

76522

Ensembl

ENSG00000128534

ENSMUSG00000044155

UniProt

O95777

Q6ZWM4

RefSeq (mRNA)

NM_016200

NM_133939

RefSeq (protein)

NP_057284

NP_598700

Location (UCSC)Chr 7: 118.18 – 118.2 MbChr 6: 18.85 – 18.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the LSm family and encodes a protein with a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. The protein partners with six paralogs to form a heteroheptameric ring which transiently binds RNAs and is involved in the general maturation of RNA in the nucleus.[6]

Interactions

LSM8 has been shown to interact with LSM2.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000128534 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000044155 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
  6. "Entrez Gene: LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)".
  7. Lehner, Ben; Sanderson Christopher M (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. ISSN 1088-9051. PMC 442147. PMID 15231747.
  8. Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. ISSN 0888-7543. PMID 14667819.

Further reading


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