LYPLA1

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.[5][6]

LYPLA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLYPLA1, APT-1, APT1, LPL-I, LPL1, hAPT1, lysophospholipase I, lysophospholipase 1
External IDsOMIM: 605599 MGI: 1344588 HomoloGene: 100781 GeneCards: LYPLA1
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q11.23Start54,046,367 bp[1]
End54,102,017 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10434

18777

Ensembl

ENSG00000120992

ENSMUSG00000025903

UniProt

O75608
Q6IAQ1

P97823

RefSeq (mRNA)

NM_008866
NM_001355712

RefSeq (protein)

NP_032892
NP_001342641

Location (UCSC)Chr 8: 54.05 – 54.1 MbChr 1: 4.81 – 4.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000120992 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025903 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA (Apr 1999). "A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization". Biochim Biophys Acta. 1437 (2): 157–69. doi:10.1016/s1388-1981(99)00012-8. PMID 10064899.
  6. "Entrez Gene: LYPLA1 lysophospholipase I".

Further reading


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