Lecithin retinol acyltransferase

Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.[5][6]

LRAT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLRAT, LCA14, lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase), lecithin retinol acyltransferase
External IDsOMIM: 604863 MGI: 1891259 HomoloGene: 3483 GeneCards: LRAT
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q32.1Start154,626,945 bp[1]
End154,753,120 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9227

79235

Ensembl

ENSG00000121207

ENSMUSG00000028003

UniProt

O95237

Q9JI60

RefSeq (mRNA)

NM_001301645
NM_004744

NM_023624

RefSeq (protein)

NP_001288574
NP_004735

NP_076113

Location (UCSC)Chr 4: 154.63 – 154.75 MbChr 3: 82.89 – 82.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester during phototransduction, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver.

Clinical significance

Mutations in this gene have been associated with early-onset severe retinal dystrophy.[6]

LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000121207 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028003 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D (Feb 1999). "Molecular and biochemical characterization of lecithin retinol acyltransferase". J Biol Chem. 274 (6): 3834–41. doi:10.1074/jbc.274.6.3834. PMID 9920938.
  6. "Entrez Gene: LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)".
  7. Brown, Gordon; Beatriz Cash; Daniela Blihoghe; Petronella Johansson; Ayham Alnabulsi; Graeme Murray (2014-03-07). "The Expression and Prognostic Significance of Retinoic Acid Metabolising Enzymes in Colorectal Cancer". PLOS ONE. 9 (3): e90776. doi:10.1371/journal.pone.0090776. PMC 3946526. PMID 24608339.

Further reading


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