Leflutrozole

Leflutrozole (developmental code names BGS-649, CGP-47645) is an aromatase inhibitor which is under development by Mereo BioPharma and Novartis for the treatment of hypogonadism in men.[1] It was also under investigation for the treatment of endometriosis, but development for this indication was discontinued.[1] As of December 2017, leflutrozole is in phase II clinical trials for hypogonadism.[1]

Leflutrozole

Clinical data
Other names	BGS-649; CGP-47645
Routes of administration	By mouth
Identifiers
IUPAC name 4-[(4-Cyanophenyl)-fluoro-(1,2,4-triazol-1-yl)methyl]benzonitrile
CAS Number	143030-47-1
PubChem CID	126735
ChemSpider	112569
UNII	RCX0IE6EJZ
ChEMBL	ChEMBL225550
CompTox Dashboard (EPA)	DTXSID80162296
Chemical and physical data
Formula	C17H10FN5
Molar mass	303.300 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)(N3C=NC=N3)F
InChI InChI=1S/C17H10FN5/c18-17(23-12-21-11-22-23,15-5-1-13(9-19)2-6-15)16-7-3-14(10-20)4-8-16/h1-8,11-12H Key:PZDLRBUQYWMNBR-UHFFFAOYSA-N