Leucyl-tRNA synthetase

Leucyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the LARS gene.[5][6]

LARS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLARS1, HSPC192, LEURS, LEUS, LFIS, LRS, PIG44, RNTLS, hr025Cl, ILFS1, Leucyl-tRNA synthetase, LARS, leucyl-tRNA synthetase 1
External IDsOMIM: 151350 MGI: 1913808 HomoloGene: 7083 GeneCards: LARS1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q32Start146,113,034 bp[1]
End146,182,650 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51520

107045

Ensembl

ENSG00000133706

ENSMUSG00000024493

UniProt

Q9P2J5

Q8BMJ2

RefSeq (mRNA)

NM_020117
NM_001317964
NM_001317965
NM_016460

NM_134137

RefSeq (protein)

NP_001304893
NP_001304894
NP_057544
NP_064502

NP_598898

Location (UCSC)Chr 5: 146.11 – 146.18 MbChr 18: 42.2 – 42.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.[6]

Interactions

Leucyl-tRNA synthetase has been shown to interact with EEF1G.[7]

Inhibitors

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000133706 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024493 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Giles RE, Shimizu N, Ruddle FH (Jan 1981). "Assignment of a human genetic locus to chromosome 5 which corrects the heat sensitive lesion associated with reduced leucyl-tRNA synthetase activity in ts025Cl Chinese hamster cells". Somatic Cell Genetics. 6 (5): 667–687. doi:10.1007/BF01538645. PMID 6933703. S2CID 11128003.
  6. "Entrez Gene: LARS leucyl-tRNA synthetase".
  7. Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
  8. Markinson B, Ghannoum M, Winter T, Rycerz A, Rock F, Gupta AK. Examining the Benefits of the Boron-Based Mechanism of Action and Physicochemical Properties of Tavaborole in the Treatment of Onychomycosis. J Am Podiatr Med Assoc. 2018 Jan;108(1):12-19. doi:10.7547/16-154 PMID 29547036

Further reading


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