Low dead space syringe

Example a low and high dead space syringe and the average fluid remaining after complete depression of the plunger.

The difference between high and low dead space syringes is determined by the average quantity of fluid that cannot be expelled from the device. Although no set standard for the designation of low dead space syringes and needles exists, it is the convention to designate any needle or syringe design that deviates from the standard needle and syringe design as low dead space if this new design yields a lower dead space.[1]

The first hypodermic needle was first used by Dr. Alexander Wood and immediately efforts were made to improve the design. It was not until 1954, with the need for massive syringe distribution of Dr. Salk's polio vaccine, that the first disposable syringes were created. Initially, they were made of glass. In 1961 plastic disposable syringes became available.[6] The advent of the first low dead space syringe occurred with the creation of 1-ml syringes designed specifically for the administration of insulin. Then amongst the scare of HIV and rising concern of other communicable diseases to healthcare workers the creation of safety syringes occurred in 1988. As of the last few years new designs have emerged that work on a needle that is low dead space and fits onto and transforms high dead space syringes into low dead space syringes. One design achieves this by creating a plunger that inserts itself into the syringe neck to expel as much fluid as possible from the syringe body, thus reducing the amount of space available within the neck.[7]

Various designs of Low dead space needle and syringes

Standard high dead space syringe and needle with extended plunger

1-ml syringe, "insulin syringe"

Standard high dead space syringe with low dead space needle

According to WHO guidelines for people who inject drugs it is suggested that needle exchange programmes provide low dead space syringes for distribution to people who inject drugs due to evidence that the provision of low dead space syringes leads to a reduction in the transmission of HIV, and hepatitis B and C.[8][9]

• Reduced drug waste.[4]
• Increase of 2-19% additional vaccine doses per vial if current 10-dose flu vaccine vials are used. Which in large flu vaccine campaigns suggests an instant increase of thousands to millions of additional persons who are vaccinated.[4]
• If 50% of people who inject drugs switch to low dead space syringes an estimated reduction of 33% of new HIV, and Hepatitis B and C infections will occur.[2]
• Reduce incidence of overdose in infants and premature babies.[5]
• Improve imaging of radiographic techniques[10]

Criticism to proponents of low dead space syringes being distributed to needle exchange programmes claim that real world pilot studies do not exist to support findings within labs. Some proponents point to America and its low prevalence of HIV and hepatitis among people who inject drugs and cite the reason for such low prevalence to low dead space syringes already being the standard preferred syringe in the United States and successful anti-needle sharing campaigns. Other critics argue that countries like Vietnam, where low dead space needles are distributed and available, have the highest rates of HIV among people who inject drugs. However, proponents claim that low dead space syringes are still difficult to get and many people who use low dead space syringes still use high dead space syringes and thus reduce the potential effect of using low dead space syringes.[11][12]