MAK (gene)

Serine/threonine-protein kinase MAK is an enzyme that in humans is encoded by the MAK gene.[5][6]

MAK
Identifiers
AliasesMAK, RP62, dJ417M14.2, male germ cell associated kinase
External IDsOMIM: 154235 MGI: 96913 HomoloGene: 31344 GeneCards: MAK
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p24.2Start10,762,723 bp[1]
End10,838,555 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4117

17152

Ensembl

ENSG00000111837

ENSMUSG00000021363

UniProt

P20794

Q04859

RefSeq (mRNA)

NM_001242385
NM_001242957
NM_005906
NM_001377262

NM_001145802
NM_001145803
NM_008547

RefSeq (protein)

NP_001229314
NP_001229886
NP_005897
NP_001364191

NP_001139274
NP_001139275
NP_032573

Location (UCSC)Chr 6: 10.76 – 10.84 MbChr 13: 41.03 – 41.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. It is expressed almost exclusively in the testis, primarily in germ cells. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. There is, however, a study of the mouse homolog that has identified high levels of expression in developing sensory epithelia so its function may be more generalized.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000111837 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021363 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ma AH, Xia L, Desai SJ, Boucher DL, Guan Y, Shih HM, Shi XB, deVere White RW, Chen HW, Tepper CG, Kung HJ (Sep 2006). "Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells". Cancer Res. 66 (17): 8439–47. doi:10.1158/0008-5472.CAN-06-1636. PMID 16951154.
  6. "Entrez Gene: MAK male germ cell-associated kinase".

Further reading


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