MB21D1

CGAS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4LEW, 4KM5, 4O67, 4MKP, 4LEV, 4O68, 4O69
Identifiers
Aliases	CGAS, C6orf150, cGAS, h-cGAS, Mab-21 domain containing 1, MB21D1, cyclic GMP-AMP synthase
External IDs	OMIM: 613973 MGI: 2442261 HomoloGene: 51384 GeneCards: CGAS
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	73,452,297 bp[1]
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)[2]
End	78,443,237 bp[2]
Gene ontology
Molecular function	• nucleotidyltransferase activity; • nucleotide binding; • metal ion binding; • GTP binding; • transferase activity; • ATP binding; • DNA binding; • cyclic-GMP-AMP synthase activity; • double-stranded DNA binding; • chromatin binding; • GO:0001948 protein binding;
Cellular component	• cytoplasm; • cytosol;
Biological process	• immune system process; • cyclic nucleotide biosynthetic process; • cellular response to exogenous dsRNA; • innate immune system; • activation of innate immune response; • defense response to virus; • positive regulation of defense response to virus by host; • cellular response to DNA damage stimulus; • positive regulation of type I interferon production; • paracrine signaling; • positive regulation of cellular senescence; • positive regulation of cGMP-mediated signaling; • positive regulation of cAMP-mediated signaling; • regulation of immunoglobulin production; • determination of adult lifespan; • regulation of type I interferon production; • regulation of immune response; • regulation of T cell activation;
	Sources:Amigo / QuickGO
Orthologs
	115004
	214763
	ENSG00000164430
	ENSMUSG00000032344
	Q8N884
	Q8C6L5
	NM_138441
	NM_173386
	NP_612450
	NP_775562
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic GMP-AMP synthase is a protein that in humans is encoded by the CGAS gene.[5] It's an enzyme, a nucleotidyltransferase, a cyclic GMP-AMP synthase.

References

GRCh38: Ensembl release 89: ENSG00000164430 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000032344 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]". Retrieved 2020-09-12.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Cyclic GMP-AMP synthase (MB21D1)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164430 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032344 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "CGAS cyclic GMP-AMP synthase [ Homo sapiens (human) ]". Retrieved 2020-09-12.

MB21D1

References

Further reading

External links