MED16

Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.[5][6][7]

MED16
Identifiers
AliasesMED16, DRIP92, THRAP5, TRAP95, mediator complex subunit 16
External IDsOMIM: 604062 MGI: 2158394 HomoloGene: 64602 GeneCards: MED16
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start867,630 bp[1]
End893,218 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10025

216154

Ensembl

ENSG00000282092
ENSG00000175221

ENSMUSG00000013833

UniProt

Q9Y2X0

Q6PGF3

RefSeq (mRNA)

NM_005481

NM_001163276
NM_198107
NM_001359629

RefSeq (protein)

NP_005472

XP_006513550.1
XP_006513551.1

Location (UCSC)Chr 19: 0.87 – 0.89 MbChr 10: 79.89 – 79.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

MED16 has been shown to interact with Thyroid hormone receptor alpha,[6] Estrogen receptor alpha[8] and Cyclin-dependent kinase 8.[6][8]

References

  1. ENSG00000175221 GRCh38: Ensembl release 89: ENSG00000282092, ENSG00000175221 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000013833 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex". Nature. 398 (6730): 824–8. Bibcode:1999Natur.398..824R. doi:10.1038/19783. PMID 10235266. S2CID 204992765.
  6. Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
  7. "Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5".
  8. Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (5): 2642–7. Bibcode:2002PNAS...99.2642K. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.