METTL3

METTL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IL0, 5IL2, 5IL1, 5K7M, 5K7U, 5K7W
Identifiers
Aliases	METTL3, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hMETTL3
External IDs	OMIM: 612472 MGI: 1927165 HomoloGene: 10501 GeneCards: METTL3
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	21,511,342 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	52,305,128 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• methyltransferase activity; • transferase activity; • RNA binding; • RNA methyltransferase activity; • mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity; • mRNA binding; • S-adenosyl-L-methionine binding; • protein heterodimerization activity; • GO:0001948 protein binding; • mRNA (N6-adenosine)-methyltransferase activity;
Cellular component	• RNA N6-methyladenosine methyltransferase complex; • nucleoplasm; • nuclear speck; • cell nucleus; • cytoplasm;
Biological process	• rhythmic process; • mRNA processing; • positive regulation of cap-independent translational initiation; • stem cell population maintenance; • primary miRNA methylation; • methylation; • mRNA methylation; • mRNA destabilization; • circadian rhythm; • primary miRNA processing; • adenosine to inosine editing; • RNA methylation; • mRNA splicing, via spliceosome; • mRNA catabolic process; • forebrain radial glial cell differentiation; • cellular response to UV; • gliogenesis; • regulation of T cell differentiation; • negative regulation of Notch signaling pathway; • regulation of meiotic cell cycle; • endothelial to hematopoietic transition; • regulation of hematopoietic stem cell differentiation; • cellular response to DNA damage stimulus; • spermatogenesis; • cell differentiation; • dosage compensation by inactivation of X chromosome; • RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	56339
	56335
	ENSG00000165819
	ENSMUSG00000022160
	Q86U44
	Q8C3P7
	NM_019852
	NM_019721
	NP_062826
	NP_062695
	Wikidata
View/Edit Human	View/Edit Mouse

N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene.[5]

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m⁶A).[5]

References

GRCh38: Ensembl release 89: ENSG00000165819 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022160 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: METTL3 methyltransferase like 3".

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bujnicki JM, Feder M, Radlinska M, Blumenthal RM (2003). "Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase". J. Mol. Evol. 55 (4): 431–44. doi:10.1007/s00239-002-2339-8. PMID 12355263.
Leach RA, Tuck MT (2001). "Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells". Int. J. Biochem. Cell Biol. 33 (10): 984–99. doi:10.1016/S1357-2725(01)00071-1. PMID 11470232.
Bokar JA, Shambaugh ME, Polayes D, et al. (1998). "Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase". RNA. 3 (11): 1233–47. PMC 1369564. PMID 9409616.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165819 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022160 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: METTL3 methyltransferase like 3".

METTL3

References

Further reading