MFZ 10-7
MFZ 10-7 (3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile) is a drug with potential applications in the treatment of addiction, which acts as a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Others of the kind, namely MPEP & MTEP, are not considered to have translational potential for human use due to off-target effects and short half-lives. Drugs of this kind have been used to offset craving for drugs of abuse such as cocaine in in vivo animal administration models.[1]
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| Formula | C15H9FN2 |
| Molar mass | 236.244 |
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References
- Keck TM, Zou MF, Bi GH, Zhang HY, Wang XF, Yang HJ, et al. (March 2014). "A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats". Addiction Biology. 19 (2): 195–209. doi:10.1111/adb.12086. PMC 3942387. PMID 24001208.
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