MIZF

Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene.[4][5]

HINFP
Identifiers
AliasesHINFP, HiNF-P, MIZF, ZNF743, histone H4 transcription factor
External IDsOMIM: 607099 MGI: 2429620 HomoloGene: 9174 GeneCards: HINFP
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25988

102423

Ensembl

ENSG00000172273

ENSMUSG00000032119

UniProt

Q9BQA5

Q8K1K9

RefSeq (mRNA)

NM_001243259
NM_015517
NM_198971

NM_172162

RefSeq (protein)

NP_751894

Location (UCSC)n/aChr 9: 44.29 – 44.31 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

HINFP is a protein that binds to a highly conserved DNA motif found in most histone H4 genes. HINFP activates H4 gene expression through interactions with the CDK2 substrate NPAT which is localized in Histone Locus Bodies. HINFP was independently described as a protein called "MBD2 interacting zinc finger protein" (MIZF). MIZF was reported to interact with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex. MIZF is thought to play a role in DNA methylation and transcription repression.[supplied by OMIM][5]

Interactions

One key partner protein of HINFP is NPAT, a CDK2 substrate that localizes to Histone Locus Bodies. MIZF has been reported to interact with Methyl-CpG-binding domain protein 2[4] and DHX9.[6]

References

  1. GRCm38: Ensembl release 89: ENSMUSG00000032119 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (Nov 2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.
  5. "Entrez Gene: MIZF MBD2-interacting zinc finger".
  6. Fujita H, Fujii R, Aratani S, Amano T, Fukamizu A, Nakajima T (Apr 2003). "Antithetic effects of MBD2a on gene regulation". Mol. Cell. Biol. 23 (8): 2645–57. doi:10.1128/MCB.23.8.2645-2657.2003. PMC 152551. PMID 12665568.

Further reading


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