MPHOSPH1

KIF20B
Identifiers
Aliases	KIF20B, CT90, KRMP1, MPHOSPH1, MPP-1, MPP1, kinesin family member 20B
External IDs	OMIM: 605498 MGI: 2444576 HomoloGene: 9418 GeneCards: KIF20B
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	89,774,939 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	34,975,745 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • microtubule motor activity; • protein homodimerization activity; • microtubule binding; • ATPase activity; • GO:0001948 protein binding; • WW domain binding; • ATP-dependent microtubule motor activity, plus-end-directed; • ATP binding;
Cellular component	• cytoplasm; • centrosome; • mitotic spindle pole; • cell projection; • spindle pole; • contractile ring; • kinesin complex; • growth cone; • microtubule cytoskeleton; • spindle; • nucleoplasm; • microtubule organizing center; • mitotic spindle midzone; • axon; • midbody; • nucleolus; • spindle midzone; • perinuclear region of cytoplasm; • microtubules; • cytoskeleton; • cell nucleus;
Biological process	• positive regulation of intracellular protein transport; • neuron projection morphogenesis; • cell division; • positive regulation of cytokinesis; • positive regulation of neuron migration; • microtubule-based movement; • positive regulation of mitotic cytokinetic process; • neural tube closure; • protein localization to microtubule; • regulation of establishment of protein localization; • cell cycle arrest; • positive regulation of cell proliferation; • regulation of neuron migration; • cell cycle; • regulation of establishment of cell polarity; • regulation of mitotic nuclear division;
	Sources:Amigo / QuickGO
Orthologs
	9585
	240641
	ENSG00000138182
	ENSMUSG00000024795
	Q96Q89
	Q80WE4
	NM_016195; NM_001284259; NM_001382506
	NM_183046; NM_001362434
	NP_001271188; NP_057279; NP_001369435
	NP_898867; NP_001349363
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF20B is a protein that in humans is encoded by the KIF20B gene.[5][6][7][8]

Interactions

MPHOSPH1 has been shown to interact with PIN1.[7]

References

GRCh38: Ensembl release 89: ENSG00000138182 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024795 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.
Westendorf JM, Rao PN, Gerace L (Feb 1994). "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope". Proc Natl Acad Sci U S A. 91 (2): 714–8. Bibcode:1994PNAS...91..714W. doi:10.1073/pnas.91.2.714. PMC 43019. PMID 8290587.
Kamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M (Oct 2001). "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1". J Biol Chem. 276 (40): 37520–8. doi:10.1074/jbc.M106207200. PMID 11470801.
"Entrez Gene: MPHOSPH1 M-phase phosphoprotein 1".

Fritzler MJ, Kerfoot SM, Feasby TE, et al. (2000). "Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)". J. Investig. Med. 48 (1): 28–39. PMID 10695267.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Abaza A, Soleilhac JM, Westendorf J, et al. (2003). "M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis". J. Biol. Chem. 278 (30): 27844–52. doi:10.1074/jbc.M304522200. PMC 2652640. PMID 12740395.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138182 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024795 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8885239-5] Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell. 7 (9): 1455–69. doi:10.1091/mbc.7.9.1455. PMC 275994. PMID 8885239.

[pmid8290587-6] Westendorf JM, Rao PN, Gerace L (Feb 1994). "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope". Proc Natl Acad Sci U S A. 91 (2): 714–8. Bibcode:1994PNAS...91..714W. doi:10.1073/pnas.91.2.714. PMC 43019. PMID 8290587.

[pmid11470801-7] Kamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M (Oct 2001). "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1". J Biol Chem. 276 (40): 37520–8. doi:10.1074/jbc.M106207200. PMID 11470801.

[entrez-8] "Entrez Gene: MPHOSPH1 M-phase phosphoprotein 1".

MPHOSPH1

Interactions

References

Further reading