MTCH2

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.[4][5][6][7]

MTCH2
Identifiers
AliasesMTCH2, MIMP, SLC25A50, HSPC032, mitochondrial carrier 2
External IDsOMIM: 613221 MGI: 1929260 HomoloGene: 8645 GeneCards: MTCH2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p11.2Start47,617,315 bp[1]
End47,642,607 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23788

56428

Ensembl

ENSG00000109919
ENSG00000285121

ENSMUSG00000027282

UniProt

Q9Y6C9

Q791V5

RefSeq (mRNA)

NM_014342
NM_001317231
NM_001317232
NM_001317233

NM_019758
NM_001317241
NM_001317242
NM_001317243
NM_001317244

RefSeq (protein)

NP_001304160
NP_001304161
NP_001304162
NP_055157

NP_001304170
NP_001304171
NP_001304172
NP_001304173
NP_062732

Location (UCSC)Chr 11: 47.62 – 47.64 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID.[8]

Clinical significance

MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis.[8]

Variants of the MTCH2 gene may be associated with obesity.[9] MTCH2 represses mitochondrial metabolism such that a deficiency of MTCH2 increases energy consumption and production by mitochondria.[8]

See also

References

  1. ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha". Molecular and Cellular Biology. 25 (11): 4579–90. doi:10.1128/MCB.25.11.4579-4590.2005. PMC 1140633. PMID 15899861.
  5. Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". Journal of Bioenergetics and Biomembranes. 37 (3): 113–9. doi:10.1007/s10863-005-6222-3. PMID 16167168. S2CID 2395673.
  6. Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?". Apoptosis. 12 (5): 869–76. doi:10.1007/s10495-007-0748-2. PMID 17453157.
  7. Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, et al. (July 2008). Chang HY (ed.). "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers". PLOS Genetics. 4 (7): e1000129. doi:10.1371/journal.pgen.1000129. PMC 2444049. PMID 18636107.
  8. Gross A (August 2016). "BCL-2 family proteins as regulators of mitochondria metabolism". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857 (8): 1243–1246. doi:10.1016/j.bbabio.2016.01.017. PMID 26827940.
  9. Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Human Molecular Genetics. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386.

Further reading

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