MTIF2

Translation initiation factor IF-2, mitochondrial is a protein that in humans is encoded by the MTIF2 gene.[5][6][7]

MTIF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMTIF2, mitochondrial translational initiation factor 2
External IDsOMIM: 603766 MGI: 1924034 HomoloGene: 1840 GeneCards: MTIF2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p16.1Start55,236,595 bp[1]
End55,269,347 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4528

76784

Ensembl

ENSG00000085760

ENSMUSG00000020459

UniProt

P46199
Q6P1N2

Q91YJ5

RefSeq (mRNA)

NM_001282118
NM_001282119
NM_001282120
NM_133767

RefSeq (protein)

NP_001269047
NP_001269048
NP_001269049
NP_598528

Location (UCSC)Chr 2: 55.24 – 55.27 MbChr 11: 29.53 – 29.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000085760 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020459 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bonner DS, Wiley JE, Farwell MA (Mar 1999). "Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16→p14 by in situ hybridization and with somatic cell hybrids". Cytogenet Cell Genet. 83 (1–2): 80–1. doi:10.1159/000015133. PMID 9925935. S2CID 23290955.
  6. Ma L, Spremulli LL (Feb 1995). "Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA". J Biol Chem. 270 (4): 1859–65. doi:10.1074/jbc.270.4.1859. PMID 7829522.
  7. "Entrez Gene: MTIF2 mitochondrial translational initiation factor 2".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.