MYCBP2

Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.[5][6]

MYCBP2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMYCBP2, PAM, Myc-bp2, Phr, MYC binding protein 2, E3 ubiquitin protein ligase, PHR1, MYC binding protein 2
External IDsOMIM: 610392 MGI: 2179432 HomoloGene: 9005 GeneCards: MYCBP2
Gene location (Human)
Chr.Chromosome 13 (human)[1]
Band13q22.3Start77,044,657 bp[1]
End77,327,094 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23077

105689

Ensembl

ENSG00000005810

ENSMUSG00000033004

UniProt

O75592

Q7TPH6

RefSeq (mRNA)

NM_015057

NM_207215

RefSeq (protein)

NP_055872

NP_997098

Location (UCSC)Chr 13: 77.04 – 77.33 MbChr 14: 103.11 – 103.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Structure

PAM contains a N-terminal leucine zipper, central MYC-binding, and C-terminal histone-binding protein homology domains.[5]

Interactions

MYCBP2 has been shown to interact with Myc.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000005810 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033004 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Guo Q, Xie J, Dang CV, Liu ET, Bishop JM (Sep 1998). "Identification of a large Myc-binding protein that contains RCC1-like repeats". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9172–7. doi:10.1073/pnas.95.16.9172. PMC 21311. PMID 9689053.
  6. "Entrez Gene: MYCBP2 MYC binding protein 2".

Further reading


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