MYO18B

MYO18B
Identifiers
Aliases	MYO18B, KFS4, myosin XVIIIB
External IDs	OMIM: 607295 MGI: 1921626 HomoloGene: 53435 GeneCards: MYO18B
Gene location (Human)
Chr.	Chromosome 22 (human)[1]
End	26,031,041 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	112,896,362 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• nucleotide binding; • actin binding; • cellular motor activity; • ATP binding; • microtubule motor activity; • microtubule binding;
Cellular component	• cytoplasm; • unconventional myosin complex; • sarcomere; • cell nucleus; • myosin complex; • Z disc; • filamentous actin;
Biological process	• microtubule-based movement; • vasculogenesis; • in utero embryonic development; • cardiac muscle fiber development;
	Sources:Amigo / QuickGO
Orthologs
	84700
	74376
	ENSG00000133454
	ENSMUSG00000072720
	Q8IUG5
	n/a
	NM_032608; NM_001318245
	NM_028901
	NP_001305174; NP_115997
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.[5][6][7]

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.[7]

References

GRCh38: Ensembl release 89: ENSG00000133454 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000072720 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A. 99 (19): 12269–74. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013.
Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197.
"Entrez Gene: MYO18B myosin XVIIIB".

Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells". Clin. Exp. Metastasis. 20 (3): 189–93. doi:10.1023/A:1022978932215. PMID 12741677.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Yanaihara N, Nishioka M, Kohno T, et al. (2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer". Int. J. Cancer. 112 (1): 150–4. doi:10.1002/ijc.20339. PMID 15305387.
Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway". Biochem. Biophys. Res. Commun. 342 (3): 829–34. doi:10.1016/j.bbrc.2006.02.025. PMID 16499872.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Edakuni N, Ikuta K, Yano S, et al. (2007). "Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice". Oncol. Res. 16 (5): 235–43. PMID 17294804.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133454 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000072720 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12209013-5] Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002). "MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad Sci U S A. 99 (19): 12269–74. doi:10.1073/pnas.192445899. PMC 129434. PMID 12209013.

[pmid12547197-6] Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation". J Mol Biol. 326 (1): 137–49. doi:10.1016/S0022-2836(02)01335-9. PMID 12547197.

[entrez-7] "Entrez Gene: MYO18B myosin XVIIIB".

MYO18B

References

Further reading